Perfusion
Research from L. Ladamoldovan et al broadens understanding of perfusion
Published in Pharma Law Weekly, September 22nd, 2009
According to recent research published in the Journal of Cardiovascular Pharmacology, "This study was designed to evaluate the effect of long-term pretreatment with celecoxib, a cyclooxygenase-2 inhibitor, on myocardial infarct size. Celecoxib (3 mg/kg/day i.p; n = 16) or vehicle (DMSO 50%; EtOH 15%; distilled water, n = 16) was administered chronically to male Sprague-Dawley rats through ALZET osmotic pumps of 28 days.Under anaesthesia, the animals were then subjected to left anterior descending coronary artery occlusion for 40 minutes, followed by 24-hour reperfusion."
"The results show that myocardial infarct size in celecoxib-treated rats was significantly...
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Source: Pharma Law Weekly (2009-09-22)
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