Enzyme Research

New enzyme research findings from University of Connecticut, Health Center published

Published in Pharma Law Weekly, October 20th, 2009

A new study, 'Inhibitors of the V0 subunit of the vacuolar H+-ATPase prevent segregation of lysosomal- and secretory-pathway proteins,' is now available. "The vacuolar H(+)-ATPase (V-ATPase) establishes pH gradients along secretory and endocytic pathways. Progressive acidification is essential for proteolytic processing of prohormones and aggregation of soluble content proteins," researchers in the United States report.

"The V-ATPase V(0) subunit is thought to have a separate role in budding and fusion events. Prolonged treatment of professional secretory cells with selective V-ATPase inhibitors (bafilomycin A1, concanamycin A) was used to investigate its role in...

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Source: Pharma Law Weekly (2009-10-20)

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