Life Sciences

Studies from P. Padaratz and co-researchers yield new data on life sciences

Published in Pharma Law Weekly, November 10th, 2009

According to recent research from Itajai, Brazil, "Chalcones represent an important group of natural or synthetic compounds with a variety of biological activities including antinociceptive and anti-inflammatory ones. The aim of this work was the synthesis of a new benzofuranone compound and evaluation of its antinociceptive potential in mice."

"The new benzofuranone 4 was synthesized from chalcone 3. The antinociceptive activity of 4 was determined by writhing, formalin, capsaicin, and glutamate and hot-plate tests. Compound 4 caused potent and dose-related inhibition against the writhing test with ID50 6.1 (5.1-7.6) mu mol/kg, i.p., being about 15 times more active...

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Source: Pharma Law Weekly (2009-11-10)

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