Sepsis

Studies from Nanjing University in the area of sepsis published

Published in Pharma Law Weekly, November 10th, 2009

"Sepsis accounts for the majority of deaths in critically ill patients. Symptoms of septic disease are often associated with monocyte/macrophage desensitization," scientists writing in the journal Proteomics Clinical Applications report.

"In the current study, impaired macrophage function was determined in a sepsis mouse model with decreased cytokine release and weak phagocytosis, coinciding with ectopic elevation of serum-ROS levels. Furthermore, in the experimental cell model, RAW264.7 macrophages displayed a ''deactivated'' phenotype, characterized by impaired inflammatory and phagocytosis function. Cellular anti-oxidative proteins were further investigated;...

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Source: Pharma Law Weekly (2009-11-10)

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