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Stem Cell Research

Studies from University of Cambridge, Medical Department provide new data on stem cell research

Published in Pharma Law Weekly, November 24th, 2009

"Severe pulmonary arterial hypertension (PAH) is characterized by the formation of plexiform lesions and concentric intimal fibrosis in small pulmonary arteries. The origin of cells contributing to these vascular lesions is uncertain," researchers in Cambridge, the United Kingdom report.

"Endogenous endothelial progenitor cells are potential contributors to this process. To determine whether progenitors are involved in the pathobiology of PAH. We performed immunohistochemistry to determine the expression of progenitor cell markers (CD133 and c-Kit) and the major homing signal pathway stromal cell-derived factor-1 and its chemokine receptor (CXCR4) in lung tissue from...

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