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Hepatitis C Virus

Research results from R. Moucari and colleagues update understanding of hepatitis C virus

Published in Pharma Law Weekly, December 29th, 2009

According to recent research from Clichy, France, "Hepatitis C virus (HCV) genotype 4 (HCV-4) is increasing in prevalence in Western countries. However, little is known about the severity of the disease and response to treatment."

"The aim of this study was to assess the predictors (logistic regression) of severe fibrosis (METAVIR score F3-F4), and sustained virological response (SVR) to peginterferon and ribavirin in 226 consecutive HCV-4 patients (Egyptians 40%, Europeans 35% and Africans 24%). Insulin resistance was assessed using the homeostasis model (HOMA-IR). Serum HCVRNA level (bDNA) and subtypes of HCV (LiPA) were determined for all patients. Insulin resistance...

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