Harborview Medical Center
AMG531 strongly stimulates megakarypoiesis in vitro
Published in Physician Business Week, March 16th, 2004
TPO "plays a pivotal role in megakaryopoiesis," and "initiates its biological effects by binding to its receptor Mp1," scientists in Seattle explained.
In a study conducted by V.C. Broudy and coauthors at Harborview Medical Center, a "recombinant protein consisting of a carrier Fc domain linked to multiple Mpl-binding domains was constructed" and named AMG531.
"To define the biological activity of AMG531," the collaborators "examined the ability of AMG531 to support CFU-Meg growth and to promote megakaryocyte maturation in vitro."
"AMG531 stimulates...
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