Aichi Cancer Center

Polymorphism increases disease risk in some premenopausal Japanese women

Published in Physician Business Week, October 12th, 2004

A polymorphism in the CYP19 gene has been linked with increased risk of breast cancer in a group of premenopausal Japanese women.

"The production of estrogen from androgen via the estrogen biosynthesis pathway is catalyzed by aromatase P450 (CYP19). To assess the association between breast cancer risk and a polymorphism at codon 39 Trpl Arg of the encoding gene, a case-control study was conducted at Aichi Cancer Center Hospital in Japan. Subjects were 248 histologically confirmed breast cancer patients and 603 hospital controls without cancer," scientists in Japan report.

"Odds ratios (OR) and 95% confidence intervals (95% CI) were determined by...

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Source: Physician Business Week (2004-10-12)

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