Hebrew University-Hadassah Medical Center
Transplantation of NKT lymphocytes suppresses hepatocellular carcinoma
Published in Physician Business Week, July 26th, 2005
According to a study from Israel and the United States, "NKT cells are a regulatory subset of T lymphocytes with immune modulatory effects and an important role in anti-tumor immunity. The feasibility of 'ex-vivo education' of NKT cells has recently been demonstrated. Here, we evaluate the anti-tumor effect of ex-vivo immune-modulated NKT lymphocytes in a murine model of hepatocellular carcinoma. Athymic BALB/C mice were sublethally irradiated and transplanted with human Hep3B HCC. NKT cells prepared from immunocompetent BALB/c mice were pulsed ex vivo with HCC-derived...
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