International Medical Center of Japan
Oligopeptide from HIV-1 Vpr improves gene expression in resting macrophages
Published in Physician Business Week, January 31st, 2006
According to recent research published in the journal Biochemical and Biophysical Research Communications, "Vpr, an accessory gene product of human immunodeficiency virus type-1, is thought to transport viral DNA from the cytoplasm to the nucleus in resting macrophages. Previously, we reported that a peptide encompassing amino acids 52-78 of Vpr (C45D18) promotes the nuclear trafficking of recombinant proteins that are conjugated with C45DI8."
"We present evidence that C45DI8, when conjugated with a six-branched cationic...
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