Columbia University
RAGE is novel target for drug intervention in diabetic vascular disease
Published in Physician Law Weekly, September 1st, 2004
"At high levels as seen in diabetes, glucose reacts with and forms adducts (advanced glycation end products; AGEs) on macromolecules including proteins and DNA, eliciting cellular dysfunction and leading to vascular disease. The major means is through cellular receptors; the best characterized is the receptor for advanced glycation end products (RAGE). Accumulation of both AGE/RAGE in addition to other identified ligands of RAGE, including S100/calgranulins, is the hallmark of this receptor in disease pathogenesis," researchers in the United...
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Source: Physician Law Weekly (2004-09-01)
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