University of Bologna

CMV prophylaxis following BMT has changed the natural history of the disease

Published in Physician Law Weekly, September 8th, 2004

Cytomegalovirus prophylaxis following bone marrow transplant has changed the natural history of the disease.

"Cytomegalovirus (CMV) is a well-known cause of disease occurring after bone marrow transplantation (BMT). The manifestations of CMV range from asymptomatic infection, defined as active CMV replication in the blood in the absence of clinical manifestations or organ failure abnormalities, to CMV disease, characterized by CMV infection with clinical symptoms or organ function abnormalities.

"Diagnostic procedures to assess the viral load have improved greatly with the increased use of antigenemia, CMV DNA, and immediate early-messenger RNA,"...

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Source: Physician Law Weekly (2004-09-08)

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