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University of Texas

Alcohol-induced genetic changes identified in individual human brains

Published in Physician Law Weekly, October 20th, 2004

Gene expression patterns associated with alcohol abuse have been identified in individual human brains.

"Chronic alcohol exposure induces lasting behavioral changes, tolerance, and dependence," scientists in the United States explained. "This results, at least partially, from neural adaptations at a cellular level."

"Previous genome-wide gene expression studies using pooled human brain samples showed that alcohol abuse causes widespread changes in the pattern of gene expression in the frontal and motor cortices of human brain," noted J.W. Liu and colleagues at the University of Texas. However, "[b]ecause these studies used pooled samples, they could...

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