Paterson Institute for Cancer Research, Lancs
Adenoviruses encoding CD40L or IL-2 effective against B cell lymphoma
Published in Physician Law Weekly, October 27th, 2004
"Some B cell lymphomas lack important costimulatory properties that could prevent them from being used as cell based vaccines. Infection of A20 B lymphoma cells with a replication-defective adenovirus encoding murine (m) CD40L, but not mIL-2, produces an antigen presentation phenotype with upregulation of MHC Class I/II, induction of B7-1/2 molecules and production of MIL-12 and MIP-1alpha. Subcutaneous vaccination with irradiated Ad-mCD40L-infected-or Ad-mIL-2-infected-A20 cells generated A20-specific CD8+ T cell responses and cross reactive A20 Ig antibodies," investigators in England...
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Source: Physician Law Weekly (2004-10-27)
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