University of Auckland

Approach may reduce the concentration of uncoupling agents in optical mapping

Published in Physician Law Weekly, October 27th, 2004

Researchers have reported on the correction of motion artifact in transmembrane voltage-sensitive fluorescent dye emission in hearts.

According to the report from new Zealand, "Fast voltage-sensitive dyes are widely used to image cardiac electrical activity. Typically, the emission spectrum of these fluorochromes is wavelength shifted with altered membrane potential, but the optical signals obtained also decay with time and are affected by contraction. Ratiometry reduces, but may not fully remove, these artifacts."

Dean C.-S. Tai and colleagues of the University of Auckland explained, "An alternate approach has been developed in which the time decay...

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Source: Physician Law Weekly (2004-10-27)

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