Kagoshima University
Thymidine phosphorylase triggers angiogenic signals in tumors
Published in Physician Law Weekly, February 23rd, 2005
According to a study from Japan, "thymidine phosphorylase (TP), an enzyme involved in pyrimidine metabolism, is identical with an angiogenic factor, platelet-derived endothelial cell growth factor (PD-ECGF). TP is overexpressed in various tumors and plays an important role in angiogenesis, tumor growth, invasion and metastasis. The enzymatic activity of TP is required for the angiogenic effect of TP."
"A novel, specific TP inhibitor, TPI, inhibits angiogenesis induced by overexpression of TP in KB/TP cells (human KB epidermoid carcinoma cells transfected with TP cDNA), as well as the...
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Source: Physician Law Weekly (2005-02-23)
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