University of Athens

CpG islands of p15INK4B gene in childhood acute leukemia were hypermethylated

Published in Physician Law Weekly, May 25th, 2005

Hypermethylation of the CpG islands in the promoter region of the p15INK4B gene was linked to childhood acute lymphoblastic leukemia (ALL).

According to published research from Greece, "It has been reported that the cyclin-dependent kinase inhibitor (CDKI) gene p15INK4B is frequently inactivated by genetic alterations and may be responsible for various malignant tumors. Another way of inactivation of this CDKI is by hypermethylation of 5'CpG islands in the promoter region of the p15INK4B gene and this inactivation seems to be a frequent event in various hematological malignancies."

"In the present study, we investigated the methylation status of the...

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Source: Physician Law Weekly (2005-05-25)

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