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AstraZeneca
Stomach acid control of proton pump inhibitors in chronic NSAID users compared
June 15th, 2005
Data from a clinical trial comparing stomach acid control of 3 proton pump inhibitors (PPIs), esomeprazole magnesium (Nexium), lansoprazole (Prevacid), and pantoprazole (Protonix), in chronic users of non-steroidal anti-inflammatory drugs (NSAIDs) were presented at the annual Digestive Disease Week (DDW). The analysis included users of traditional NSAIDs and selective COX-2 inhibitors. The results of the multicenter, randomized, 3-way, crossover study of 77 chronic users of COX-2 inhibitors or nonselective NSAIDs found that esomeprazole maintained a pH of greater than 4.0 for 17.8 hours (74.3%) of the 24-hour period while lansoprazole maintained it...
Source: Physician Law Weekly (2005-06-15)
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