Physician Law Weekly
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Autonoma University, Madrid
Statins diminish NF-kappa-B activation by inhibiting IKK-1/-2, p38, and p42/44
June 22nd, 2005
HMG-CoA reductase inhibitors reduce I kappa B kinase activity induced by oxidative stress in monocytes and vascular smooth muscle cells. According to recent research from Spain, "Reactive oxygen species, such as superoxide anion (02- ) and hydrogen peroxide (H2 O2 ), may act as second messengers of intracellular signaling and play a key role in the pathogenesis of atherosclerosis. The nuclear factor kappa B (NF-kappa B) is a redox-sensitive transcription factor that is involved in this process." "The aim of [our] study was to investigate the molecular mechanisms of action of statins on cultured vascular smooth muscle...
Source: Physician Law Weekly (2005-06-22)
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