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Baylor College of Medicine, Houston
Mifepristone-controlled transgenes model cardiac phenotypes in mice
June 22nd, 2005
Mifepristone-controlled transgenes model cardiac phenotypes in mice. "Conditional transgene expression in the heart is a useful approach to explore the physiological basis of the cardiac phenotype. The present study describes the development of a binary transgenic system in which transgene expression in the mouse heart can be turned on/off by administration/withdrawal of an exogenous compound," scientists writing in the Journal of Molecular and Cellular Cardiology report. "We generated a transgenic line (alpha MHC-Glp 65) harboring a mifepristone (RU486)-controlled chimeric transcription factor (Glp 65) under the regulatory control of the...
Source: Physician Law Weekly (2005-06-22)
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