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Children's Hospital Oakland

Investigational meningitis vaccine immunogenic in children

Published in Physician Law Weekly, October 5th, 2005

An investigational quadrivalent Neisseria meningitidis diphtheria toxoid conjugate vaccine is protective in children but may require booster for sustained protection.

"One dose of a quadrivalent meningococcal conjugate (MC-4) vaccine elicits higher group C bactericidal responses in two-year olds than a U.S.-licensed quadrivalent polysaccharide (MPS-4) vaccine. The objective was to assess immunogenicity and persistence of serum antibody to capsular groups A, Y, and W-135 in two-year old children immunized with MC-4 vaccine. Measurement of antibody responses in sera from a multicenter randomized trial comparing MC-4 and MPS-4 vaccines," scientists in the United...

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