University of Tokushima

Kidney cell phosphate transporter studied, down-regulation clarified

Published in Physician Law Weekly, October 5th, 2005

Recent research from Japan has reported on the role of membrane microdomains in parathyroid hormone (PTH)-mediated down-regulation of type IIa sodium-dependent phosphate transporter (NaPi-Iia) in opossum kidney cells (OK-N2).

"PTH rapidly down-regulates NaPi-IIa via an endocytic pathway. Since the relationship between PTH signaling and NaPi-IIa endocytosis has not been explored, we investigated the role of membrane microdomains in this process," wrote K. Nashiki and colleagues, University of Tokushima.

"We examined the submembrane localization of NaPi-IIa in opossum kidney OK-N2 cells that stably expressed human NaPi-IIa, and searched for a...

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Source: Physician Law Weekly (2005-10-05)

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