Nara Medical University
PARP-1 required for HIV-1 integration near the centromere region
Published in Physician Law Weekly, October 5th, 2005
"This study examined the efficiency of human immunodeficiency virus type 1 (HIV-1) integration in poly(ADP-ribose)polymerase-1 (PARP-1)-deficient murine cells and in human cell lines transfected with small interfering RNA against PARP-1 (PARP-1 siRNA).
"To semiquantify the amount of integrated HIV-1 genome, real-time nested PCR was carried out using primers specific for Alu and alphoid DNA combined with primers for the HIV-1 genome," researchers in Japan report.
"The results showed that the integration efficiency of the HIV-1 genome near Alu...
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Source: Physician Law Weekly (2005-10-05)
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