Physician Law Weekly

Neuroscience - Structural proteins and angiogenic factors highlight aneurysm rupture

New River Pharmaceuticals Inc. - New drug application filed with U.S. FDA for treatment of pediatric ADHD

New York University - Nickel compounds stimulate vascular endothelial growth factor expression

Nihon University, Kanagawa - Recombinant granulocyte colony-stimulating factor influences neutrophil apoptosis

Niigata University - Naked plasmid DNA-encoding CTLA4-Ig gene prevents autoimmune myocarditis

North Carolina State University - Endothelial cells, astrocytes, and microglia may play role in trafficking of different PBMC subsets

North Dakota State University - A novel in situ forming gel system for insulin delivery was biocompatible

Northwestern University, Chicago - Recovery is possible for patients with pure red cell aplasia and anti-erythropoietin antibodies

Norwegian American Hospital - Chicago hospital names Maribel A. Torres as vice president of patient care

NuVasive, Inc. - Medical device company appoints Jeffrey Rydin as senior vice president of U.S. sales

OSI Pharmaceuticals, Inc. - Phase IIa trial shows type 2 diabetes treatment substantially reduces glucose levels

Omnicell, Inc. - Patient safety solutions provider unveils point-to-point medication safety solutions

Orthovita, Inc. - Study of Cortoss using the vertebroplasty technique shows pain improvement

Osaka Medical Center for Cancer and Cardiovascular Diseases - High volume hospitals may have improved uterine cancer survival rates

Osteotech, Inc. - U.S. FDA grants clearance for DBM paste products as bone fillers

Outcome Sciences, Inc. - Company chosen to lead development of standards for patient registries

PPD, Inc. - Contract research organization expects higher than predicted revenues of up to$1.14 billion

PPD, Inc. - License agreement signed for discovery of biomarkers for renal cell carcinoma

PTC Therapeutics, Inc. - Biopharma company initiates phase II study of cystic fibrosis treatment

Palatin Technologies, Inc. - Biopharma company discusses potential health risk associated with NeutroSpec

Patient Safety - Progress is slow in improving hospitals' patient safety systems

Pediatrics - Clinical features uncover cutaneovisceral angiomatosis with thrombocytopenia

Pennsylvania State University - Fish gene sheds light on human skin color variation

Peregrine Pharmaceuticals, Inc. - Avid Bioservices to manufacture a recombinant human enzyme

Personnel - Cirrus Health appoints Shalicia Neal director of nursing at Spring Creek Surgery Center

Personnel - George W. Foyo to join Blue Cross and Blue Shield of Florida as market president - south Florida

Personnel - HMA appoints Vicki A. O'Meara to board of directors

Personnel - Harris Methodist H-E-B Hospital names Kirk King new president

Personnel - Howard Aihara promoted to executive VP and chief financial officer of Alliance Imaging

Personnel - Steven W. Cooley, MD, named president of operations of telephone medical consult firm

Pfizer Global Research & Development - Mitochondria are involved in exercise-induced cerivastatin muscle toxicity

Policlinico University, Messina - Identified mannoproteins are important targets of antibody response during cryptococcosis

Precision Wire Components, LLC - Component maker earns medical quality system registration

Presbyterian Hospital of Dallas - Report presents U.S. perspective on biological drug indications and monitoring

Prison Health - California awards cost-saving pharmaceuticals contracts for parolees, people in state institutions

Protalex, Inc. - Biotech company begins phase I clinical trial of PRTX-100 for autoimmune diseases

QualityMetric Incorporated - Outcomes measurement company reviews accomplishments of grant contracts

Rabin Medical Center, Petah Tiqwa - Nonmyeloablative conditioning does not prevent telomere shortening after ASCT

Radiation Therapy Services, Inc. - Radiation therapy center operator secures commitment for $100 million in debt financing

Radiometer America Inc. - Blood gas testing company selects HealthStream to develop and deliver education program

Rambam Medical Center, Haifa - Pediatric nasopharyngeal carcinoma cured by combined radiation and chemotherapy

Regional Research Laboratory, Jammu - Microplate nitrate reductase assay rapidly determines antibiotic susceptibility of MTB isolates

RemedyMD - Software solutions provider announces a new suite of products for physicians

Research & Markets Ltd. - Korean pharmaceutical market is focus of new report

Research Institute Child Nutrition, Dortmund - Long-term protein intake is linked to bone modeling at proximal radius in children

Retail Healthcare - First Manhattan RediClinic launches near Times Square

Rite Aid Corporation - Retail drug store reports 2.6% increase in same store sales

Robert Jones & Agnes Hunt Orthopedic & District Hospital, Shrops - A-utrophin may be associated with tumors

Romark Laboratories - Study shows warfarin effectiveness not inhibited by Alinia in patients with CDAD

Royal Brisbane & Women's Hospital - By eliminating scar tension, paper tape may reduce hypertropic scarring

Royal Free University College, London - HIV/TB coinfected donors have increased IL-4 and IFN-gamma in whole blood and lung lavage fluid

SFBC International, Inc. - Drug development company implements plans to ensure its ability to conduct business

SUNY Upstate Medical University - Mild and advanced liver fibrosis differences imaged in chronic hepatitis C

SUNY Upstate Medical University - Treatment with LMWH plus warfarin reduces accuracy of point-of-care INR testing

Saint Johns Medical College, Bangalore - Energy costs for physical activities are reported

Saint Johns National Academy Health Science, Karnataka - Consequences of inadequate food energy and negative energy balance in humans are discussed

Saint Louis University - Four-question screening tool can predict which patients are likely to lose weight

Saint Louis University - SNAQ and CNAQ measure appetite and predict weight loss in community or long-term care adults

Salivary Glands - Histopathological and clinical features of large-cell undifferentiated carcinoma of the submandibular gland reviewed

Samaritan Pharmaceuticals Inc. - U.S. patent allowance covering PBR protein technology announced

Schering AG, Germany - Three phase II clinical trials to evaluate anticancer compound ZK-EPO

Schering-Plough Corp. - RapidFire lead discovery collaboration expanded

Second Military Medical University, Shanghai - Arterial baroreflex dysfunction linked to pathogenesis

Sine-Off - Maker of decongestants removes pseudoephedrine from products to curb meth abuse

SonoSite, Inc. - Agreement signed to distribute hand-carried ultrasound devices for neurosurgery

Soroka University Medical Center, Beer Sheva - Epley's maneuver suitable for management of bilateral BPPV

Soroka University Medical Center, Beer Sheva - Vaccinating toddlers against hepatitis A in one Israeli community reduced overall incidence

South Africa National Institute of Occupational Health - Pathogenic Legionella species and legionella-laden amoebae isolated in dental unit waterlines

Spectrum Pharmaceuticals, Inc. - Target enrollment achieved in satraplatin phase III trial for prostate cancer

Spedali Riuniti Livorno - Ultrasonography valued for usefulness in identifying the most aggressive cancers

St. Jude Children's Research Hospital, Memphis - Scythe protein is critical to lungs, kidney and brain development

St. Jude Children's Research Hospital, Memphis - TRAF3 protein may be a key to early immune response to viruses

St. Mary's Hospital, Rochester - Leptin alters endothelial progenitor cell functionality

St. Vincent's Comprehensive Cancer Center, New York - New York cancer center installs imaging system for lung cancer diagnosis, biopsy

Stanford University - Report describes use of mechanical thrombectomy in a postoperative neonate

Stanford University Medical Center - Medical center announces new statistical tool to assist with cancer research

StayinFront, Inc. - Roche extends use of customer relationship management software

Steno Diabetes Center, Rotterdam - Spironolactone plus antihypertensive therapy lowers blood pressure in diabetic nephropathy

Stockholm University - Mycobacteria exposure primes immune system for evolutionarily diverse heat shock proteins

Surface Logix Inc. - Trial of PDE5 inhibitor in patients with vascular endothelial dysfunction underway

Suros Surgical Systems, Inc. - Breast biopsy systems receive European CE Mark sales approval

Synovis Life Technologies, Inc. - Surgical devices developer reports record revenue for fourth quarter and FY2005

TB Research Center, Tamil Nadu - Drug regimens effective for treatment of lymph node tuberculosis

TeamHealth - Private equity firm completes acquisition of physician staffing company

Telzuit Medical Technologies, Inc. - Company focused on mobile medicine hires PR and investor relations services firm

Teva Pharmaceutical Industries Ltd. - Generic drug company draws down on new US$350 million syndicated loan facility

Texas Children's Hospital, Houston - Acellular porcine dermal collagen likely useful for non-aesthetic soft tissue augmentation

The Institute For Genomic Research - Researchers reveal genome of bacteria that lives in Spanish lagoons

The Mentholatum Company, Inc. - Healthcare products company acquires Phisoderm brand

The Quigley Corporation - QR-336 shown to protect against lethal doses of ionizing radiation

The Quigley Corporation - U.S. FDA issues investigational new animal drug number for study of avian flu on pigs

TheraVitae - Biotech company presents results showing angina patients improve after adult stem cell therapy

Thorne Research - Nutritional supplement may help African Americans with cardiovascular problems

Toshiba America Medical Systems Inc. - Ted Nemetz named VP, technology services unit, of diagnostics imaging systems company

Tufts University School of Veterinary Medicine - Shiga toxin 2 antibodies prevent fatal systemic complications from E. coli O157:H7

Tufts University, Boston - Future studies could predict who will benefit from low glycemic load diet

Tufts University, Cummings School of Veterinary Medicine - Antibody-based fluorescence assay correlates with PCR for E. bieneusi spore detection

U.S. Centers for Disease Control & Prevention - Report compares multiplex assays for detecting Borrelia in Ixodes nymphs

U.S. Food & Drug Administration - Biomarkers of marine neurotoxicant domoic acid have been identified

U.S. National Cancer Institute - Vectors encoding for costimulatory molecules enhance immunogenicity of leukemia cells

U.S. National Institute for Occupational Safety & Health - Deficiency in Ikk beta gene enhances arsenic-induced gadd45 alpha expression

U.S. National Institute of Mental Health - Brain chemical appears to boost trust and reduce fear

U.S. National Institutes of Health - Janus kinase 3 negatively regulates dendritic-cell cytokine production and survival

U.S. National Institutes of Health - KSHV K8 beta blocks K8 alpha-CDK2 interaction

U.S. National Institutes of Health - Replication-competent HIV persists in patients with uninterrupted HAART

ULURU Inc. - Discus Dental granted sole U.S. distribution rights to drug for aphthous ulcers

Unilens Vision Inc. - Contact lens manufacturer reports 37% increase in first quarter 2006 earnings

Universidad de Valencia - Antisense gene therapy is efficacious in colorectal cancer

Universidade Federal de Minas Gerais - Relative frequency of odontogenic tumors in a Brazilian population determined

Universite Rene Descartes, Paris - Hepatitis C virus found in the semen of men coinfected with HIV-1

University Autonoma Madrid - Crowding agents mimic the crowded environment inside the HIV-1 virion

University Autonoma Madrid - Failures of lopinavir/ritonavir monotherapy can be successfully reinduced

University College London - Algorithm for risk of ovarian cancer is useful with postmenopausal women

University Health Network, Toronto - Abbreviated Hamilton Depression Rating Scale equally valid for remission assessment

University Hospital of North Norway, Tromso - PWTD imaging is more sensitive than ECG in detecting subtle LV function changes

University Hospital of Puerta Mar, Cadiz - Vascular related molecules signal active rheumatoid arthritis

University Medical Center Groningen - New software eases glucose monitoring in critically ill patients

University Medical Center St. Radboud, Nijmegen - New anticoagulants in adjuvant therapy for ischemic heart disease are reviewed

University Medical Center, Groningen - With proper placement, ACL graft can replicate tension curve of healthy ligament

University at Buffalo - Prepregnancy weight is increasing and may result in more pregnancy-related complications

University of Alabama - D-H gene segment is sufficient for B cell development and immune function

University of Alabama - Review indicates PYY3-36 is not effective antiobesity drug target

University of Alabama - Treatment decisions affect QoL but not overall cervical cancer survival

University of Alberta - Most harm to child's mental health happens in years before parents divorce

University of Arizona - Redox signature score identifies patients with poor prognosis

University of Arkansas for Medical Sciences - Distribution of positive lymph nodes in patients with N0 oropharyngeal carcinoma assessed

University of Barcelona - Using higher cutoff reduces sensitivity of Hybrid Capture II assay

University of Basel Hospital - Pharmacotherapy in HIV/AIDS patients with cardiovascular symptoms is complex

University of Bayreuth - Plasmid-based vectors for B. subtilis with structural stability have been developed

University of Bologna - Review discusses fatty liver disease treatment associated with the metabolic syndrome

University of Bristol - Folic acid may not have a role in cardiovascular disease prevention

University of British Columbia - HAART interruption is a viable option when nadir CD4 cell counts are >250 cells/mm³

University of British Columbia - Pulsatile insulin release in elderly can be improved by s.c. administration of GLP-1

University of Calgary - Partial gene deletion of H-FABP limits dietary-induced insulin resistance severity

University of California, Berkeley - People exposed to ionizing radiation may be at increased risk of developing melanoma

University of California, Davis - Imiquimod and CpG ODN induce antiviral cytokines but do not prevent vaginal SIV

University of California, Irvine - Neuropeptide S has arousal-promoting and anxiolytic effects

University of California, San Diego -  Mycobacterium smegmatis mycothiol synthase mutant has an altered thiol redox status

University of California, San Francisco - Health-related quality of life and estimates of utility are low in CKD patients

University of California, San Francisco - Persistent microbial infection garners immune activation and airway remodeling

University of Cambridge - Lentiviral vector in Pluronic F127 gel facilitates delivery to CNS

University of Chicago - Postprandial E levels related to glucose and insulin levels breaks down with age

University of Cincinnati - Norovirus capsid protein forms particle that binds to histo-blood group antigen receptors

University of Colorado - Anti-CD23 agents such as Lumiliximab hold promise as a potential therapy for allergic diseases

University of Colorado - Self-reported HAART adherence and saquinavir AUC predict virologic response

University of Edinburgh - Research findings may lead to a new understanding of and treatment for MS

University of Florida - Calpain-calpastatin inhibits lung endothelial nitric oxide synthase

University of Florida - Neurofibromin-deficient Schwann cells are tumorigenic in NF1 knockout mice

University of Florida - Tooth-decay bacteria can survive without important biochemical pathway

University of Gottingen - Octyl-methoxycinnamate in sunscreen has estrogenic and nonestrogenic toxicity

University of Groningen - Glomerular filtration rate, elevated urinary albumin may detect increased cardiac and renal risk

University of Hawaii - Dietary changes due to acculturation of Korean women may affect chronic disease risks

University of Hong Kong - Lack of aldose reductase production prevents diabetes-related retinopathy in animal models

University of Iceland, Reykjavik - Prevalence of hepatitis B virus genotypes is changing in Iceland

University of Illinois - Diabetes mellitus patients experience decreased cardiac myofilament function

University of Iowa - Vascular adaptations offer stability in fetal sheep with chronic anemia

University of Jena - Maternal dietary habits indicate obesity risk in children of gestational diabetic mothers

University of La Rioja, Logrono - Quaternary ammonium compound-based agents are effective against foodborne outbreak strains

University of Lagos - Oral lesions are indicators of HIV infection among dental patients in Nigeria

University of Leuven - A low UVB dose increases keratinocyte resilience against future UVB insults

University of Liverpool, Prescot - Breast tumor localized with a metal coil before administration of neoadjuvant chemotherapy

University of London Imperial College of Science, Technology, & Medicine - Zoledronate induced apoptosis in imatinib-resistant chronic myeloid leukemia cells

University of Louis Pasteur Strasbourg, Illkirch Graffenstaden - Dimerization of poly(ADP-ribose) polymerase-1 triggers its activation

University of Mainz - Malnutrition experienced by patients with head and neck cancer

University of Maryland - Nucleobase analogues display marginal anti-hepatitis B and C virus activities

University of Maryland - Scientists find a clue to the cause of accelerated aging disease

University of Massachusetts - HIV-1-specific CD8+ T cell responses are factors in viral evolution in mothers/infants

University of Michigan - A gene variation may affect tamoxifen's benefit in breast cancer

University of Michigan - Androgens may be useful in cardiovascular risk assessment profile for women

University of Michigan - Effect of estrogens on fibrinolytic factors may reduce CV disease risk

University of Michigan - Income level should be considered when developing educational mammography interventions

University of Michigan - Perceived severity of cardiac disease is less for women than men

University of Michigan - Should surgery for stress urinary incontinence include pelvic organ prolapse surgery?

University of Michigan - Surgeon perspectives about local therapy for breast carcinoma shared

University of Minnesota - Review focuses on key issues in end point selection for heart failure trials

University of Missouri - Association between cardiac toxicity and antineoplastic agents discussed

University of Modena - Interruptions of shorter periods are unlikely to allow restoration of mitochondrial DNA

University of Montreal - Exposure to a low-protein diet in utero spawns microvascular dysfunction

University of Montreal - Serum albumin modifications in early diabetes could increase severe glomerulopathy risk

University of Nebraska - Coconut oil increases CLA-induced body fat loss independent of essential fatty acid level

University of Nebraska - HSV locus increases encephalitis risk in male mice

University of Nebraska - Macrophage-induced inflammation affects neuronal development in HIV-1 encephalitis

University of Newcastle - Physicians must be informed about naturopathy/herbalism use among cancer patients

University of North Carolina - Chronic ethanol sensitizes the liver to endotoxin

University of North Carolina - Valacyclovir reduces risk of HSV-2 transmission between HSV-2 discordant couples

University of Pennsylvania - Papillomavirus-associated squamous cell carcinoma developed in dog after chronic cyclosporine

University of Perugia - Aortic stiffness increased in HIV/AIDS patients receiving protease inhibitors

University of Pittsburgh - Adolescent alcohol use disorders predict adult borderline personality

University of Pittsburgh - Hormone replacement therapy did not enhance physical performance for elderly women

University of Pittsburgh - Method is developed to monitor immune function in bowel transplant recipients

University of Pittsburgh - The long-term clinical course for teenagers with major depression is poor

University of Pittsburgh School of Medicine - Scientists identify genes linked to cognitive longevity

University of Queensland - Model of immunity to Burkholderia pseudomallei is developed

University of Regensburg - Parvovirus B19 VP2-proteins have been produced in Saccharomyces cerevisiae

University of Rennes - Heart rate variability indexes are reliable measures in healthy older women

University of Ryukyus, Okinawa - 3D checkerboard assay quantitatively determines synergy for multiple antimycobacterial agents

University of Sao Paulo - Amaranth snacks cause insulinemic response in women with celiac disease

University of Sao Paulo - Novel gene transfer strategy improves tumor cell inhibition

University of South Florida - Cholangiocarcinoma patients should receive adjuvant treatment and aggressive tumor resection

University of South Florida Health - Improving coping skills benefits family caregivers of hospice patients with cancer

University of Southern California - Animal study suggests anabolic steroids may be addictive

University of Texas Health Center, Tyler - ELISPOT is as good as tuberculin skin testing to detect latent TB infection

University of Texas SW Medical Center, Dallas - Megf7 deficiency causes abnormal apical ectodermal ridge development and polysyndactyly

University of Texas, San Antonio - Rats fed high fat and low STZ diet developed type 2 diabetes and pronounced kidney lesions

University of Toronto - Stem cell factor bolsters myocardial repair after cell transplantation

University of Udine - Carriage of ApoE epsilon 4 affects fibrosis progression of recurrent hepatitis C

University of Ulsan, Seoul - Adefovir alone or with lamivudine gives comparable results against hepatitis B virus

University of Utrecht - Sweet taste and energy content are needed for hypothalamic response

University of Verona - Constitutive kinase activation in myasthenic thymus preludes IL-6 and RANTES overexpression

University of Vienna - New mechanism has been defined for virus neutralization by soluble receptors

University of the Saarland - Lipid-based nose ointment shows promise for treatment

University of the Sacred Heart, Rome - Transplanted neural stem cells remedy injured spinal cords in mice

Unotron - Company introduces washable corded optical computer mice to halt spread of infection

V. Cervello Hospital, Palermo - Protein alterations after hernioplasty may affect wound healing

Veretebron Inc. - Small stature cervical plate system offers better fit for patients

Veteran Affairs Medical Center, Birmingham - Changes in A_1c levels can be used to assess quality of diabetes care

Veterans Affairs Puget Sound Health Care System, Seattle - The postnatal rat aorta harbors pericyte progenitors with differentiation capabilities

Virginia Polytechnic Institute & State University - HIV-1 Tat upregulates IL-6 and IL-8 expression in breast cancer cells

Wadsworth Center, Albany -  Cryptococcus gattii is highly prevalent among AIDS patients in southern California

Wake Forest University, Winston-Salem - New data regarding biochemistry of angiotensin-(1-7)-forming enzymes are reviewed

Walter & Eliza Hall Institute of Medical Research, Parkville - NF-kappa B1 and c-Rel are critical during pDC differentiation

Washington University, Saint Louis - Coronary artery calcification, diabetes, and hypertension increase atherosclerosis risk

Washington University, Saint Louis - Polymorphisms in the K_ATP channel may increase type 2 diabetes risk

Washington University, St. Louis - Gene transfer can be imaged using MicroPET

Wayne State University, Detroit - Apoptotic stress is offset by elements preventing neuron death in type 1 diabetic rat model

Weizmann Institute of Science, Rehovot - Colon cancer seizes hapless nerve growth protein, according to a new study

Wyeth - U.S. FTC will not file objections to settlement of patent dispute over venlafaxine

Wyeth - U.S. NIH awards $32 million contract for ongoing HIV vaccine research

XenoPort, Inc. - Agreement signed for rights to develop gabapentin prodrug in Japan and other Asian countries

Yale University - Dopamine transporter and receptor gene polymorphisms linked to ADHD

Yale University - Incarceration and race disparities in U.S. HIV rates is the focus of a new study

Yale University - Langerhans cells reported to inhibit immune responses in the skin

Yale University - New evidence supports the century-old theory of how cancer spreads

Yale University - Racial minorities are willing to participate in health research when there is an opportunity

Yamaguchi University - Angiopoietins reflect angiogenic changes in the corpus luteum

Yokohama City University - Chromatin structure may predispose to recombination hotspots in genomic disorders

Zeneus Holdings, Ltd. - Cephalon announces agreement to acquire holding company

diaDexus, Inc. - Data shows 11-fold higher stroke risk associated with elevated Lp-PLA2

eDiets.com, Inc. - Humble to retire as CEO of diet company

iJET Intelligent Risk Systems - Risk management services provider advises companies to prepare for avian flu pandemic

iVoice, Inc. - Nonbinding letter of intent signed for acquisition of Thomas Pharmaceuticals

instaCare Corp. - E-health technology developer reports Q3 2005 increase in revenues