University of Colorado
Impaired DNA replication within progenitor cell pools promotes leukemogenesis
Published in Physician Law Weekly, February 8th, 2006
"Impaired cell cycle progression can be paradoxically associated with increased rates of malignancies. Using retroviral transduction of bone marrow progenitors followed by transplantation into mice, we demonstrate that inhibition of hematopoietic progenitor cell proliferation impairs competition, promoting the expansion of progenitors that acquire oncogenic mutations which restore cell cycle progression," wrote G. Bilousova and colleagues, University of Colorado.
"Conditions that impair DNA replication dramatically enhance the...
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Source: Physician Law Weekly (2006-02-08)
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