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Sun Yat Sen University, Guangzhou

Adenovirus-mediated gene delivery inhibits nasopharyngeal tumor growth

Published in Physician Law Weekly, May 24th, 2006

According to recent research from the People's Republic of China, adenovirus-mediated intra-tumoral delivery of the human endostatin gene inhibits tumor growth in nasopharyngeal carcinoma (NPC).

"The growth and metastasis of NPC, one of the most common cancers in southern China, is closely related to neovascularization. Here, we examined whether intratumoral delivery of endostatin gene could lead to long-term local expression of bioactive endostatin at therapeutic levels," wrote L. Li and colleagues, Sun Yat Sen University.

"We constructed a recombinant adenoviral vector carrying the human endostatin gene (Ad/hEndo), which expressed high-level...

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