University of Bonn, Germany

Maternal and embryonic transcripts selectively degraded

Published in Physician Law Weekly, July 26th, 2006

A study from Germany has reported on the selective degradation of maternal and embryonic transcripts in in vitro produced bovine oocytes and embryos using sequence specific double-stranded RNA.

"RNA interference (RNAi) has been used for selective degradation of an mRNA transcript or inhibiting its translation to a functional protein in various species. Here, we applied the RNAi approach to suppress the expression of the maternal transcript C-mos and embryonic transcripts Oct-4 in bovine oocytes and embryos respectively, using microinjection of sequence-specific double-stranded RNA (dsRNA)," wrote K. Nganvongpanit and colleagues, University of Bonn.

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Source: Physician Law Weekly (2006-07-26)

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