University of British Columbia, Canada

Cancer inhibition by sulindac and its metabolite involves differential mechanisms

Published in Physician Law Weekly, July 26th, 2006

Cancer inhibition by sulindac and its metabolite involves differential mechanisms.

According to recent research from Canada, "Non-steroidal anti-inflammatory drugs such as sulindac inhibit human colorectal carcinogenesis through a mechanism involving the direct inhibition of cyclooxygenase (Cox)-2. However, a wealth of recent evidence indicates that these agents might elicit their effects through mechanisms independently of Cox-2."

"In this study, we investigated the effects of sulindac and its metabolite, sulindac sulfide on modulation of the critical survival kinase, protein kinase B (PKB). Here, we demonstrate for the first time that treatment...

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Source: Physician Law Weekly (2006-07-26)

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