HSV-1

Model of the Surface of DNA Is Presented

Published in Proteomics Weekly, November 2nd, 1998

Researchers presented a model of the surface DNA that interacts with a sequence-specific binding protein for herpes simplex virus type 1 (HSV-1).

The UL9 gene of HSV-1 encodes an origin binding protein (OBP). It is an ATP-dependent DNA helicase and a sequence-specific DNA-binding protein. The latter function is carried out by the C-terminal domain of OBP (Delta OBP).

S. Simonsson et al. performed a quantitative analysis of the interaction between Delta OBP and its recognition sequence, GTTCGCAC ("The Herpes Simplex Virus Type 1 Origin Binding Protein - Specific Recognition of Phosphates and Methyl Groups Defines the Interacting Surface for a...

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Source: Proteomics Weekly (1998-11-02)

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