Published in Proteomics Weekly, November 2nd, 1998
The UL9 gene of HSV-1 encodes an origin binding protein (OBP). It is an ATP-dependent DNA helicase and a sequence-specific DNA-binding protein. The latter function is carried out by the C-terminal domain of OBP (Delta OBP).
S. Simonsson et al. performed a quantitative analysis of the interaction between Delta OBP and its recognition sequence, GTTCGCAC ("The Herpes Simplex Virus Type 1 Origin Binding Protein - Specific Recognition of Phosphates and Methyl Groups Defines the Interacting Surface for a...
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