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Cell Biology

A new role for a versatile stem cell

Published in Proteomics Weekly, June 10th, 2002

Recent work has prompted a dramatic shift in thinking about cell regeneration, as researchers have come to appreciate the ability of adult stem cells to adopt the fates of many cell types, not just those in a particular tissue or a specific developmental lineage.

The Verfaillie laboratory has shown that multipotent adult progenitor cells (MAPCs), a marrow-derived stem cell type with an impressive developmental repertoire, can be prepared from humans or rodents and can be used to reconstitute cells of all embryonic lineages when injected into a blastocyst. Technically more demanding but also more useful if the hope is to develop therapeutic engraftment techniques using...

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