Infectious Disease

Pseudomonas resistance protein Ohr characterized

Published in Proteomics Weekly, February 17th, 2003

Researchers at Cornell University have shed new light on one of the proteins conferring high-level drug resistance to Pseudomonas pathogens.

"Bacteria have developed complex strategies to detoxify and repair damage caused by reactive oxygen species. These compounds, produced during bacterial aerobic respiration as well as by the host immune system cells as a defense mechanism against the pathogenic microorganisms, have the ability to damage nucleic acids, proteins and phospholipid membranes," explained J. Lesniak and colleagues.

The researchers investigated the "crystal structure of Pseudomonas aeruginosa Ohr, a member of a recently...

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Source: Proteomics Weekly (2003-02-17)

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