Proteomics Weekly

Immune Surveillance - L-selectin (CD62L) is particular to a set of resting memory CD4(+) T cells

Immunology - Research in poxvirus production to speed up vaccines

Infectious Disease - Mast cells play key role in early response to Pseudomonas aeruginosa

Interferon-like Cytokine - Mature T lymphocytes, bronchial and salivary cells produce limitin glycoprotein

Kidney Stones - Osteopontin is the natural inhibitor of calcium oxalate crystal formation

Leukemia - Researchers discover how virus spreads through the body

Lithium Chloride Therapy - Brain phospholipase A2 level was reduced without affecting phosphorylation

Liver Fibrosis - Green tea antioxidant lowers activated stellate cells, gene products

Lupus - Genetic 'signature' linked to severe symptoms

Lymphoma - Epstein-Barr virus' LMP1 has a TRAF binding domain; it can activate JNK

Malaria Pathogenesis - Hepatocyte CD81 expression needed for plasmodial sporozoite infectivity

Malaria Therapy - Protein apical membrane antigen-1 inhibitors block merozoite cell entry

Mitochondrial DNA - A8344G mutation is associated with strokes and a paralytic intestine

Multiple Sclerosis - CCR2(-/-) EAE mouse models produce disease through a compensatory pathway

Neonatal Medicine - Serum osteocalcin components differ in cord and day 5 blood

Neurite Outgrowth - HSP70-positive astrocytes will not support outgrowth following heat shock

Ocular Cancers - Screening for pRB and mutation analysis may lead to improved survival

Opportunistic Infection - IL-10 modulates Pneumocystis carinii-induced lung damage

Orphan Nuclear Receptors - Rev-erb alpha expression is transcriptionally regulated by ROR alpha

Osteoblast Protection - TGF-beta 1 inhibits caspases and apoptosis induced by TNF-alpha

Ovarian Epithelial Cells - ATP activates the mitogen-activated protein kinase in neoplasia

Phytochemotherapy - A lectin from tepary bean may be considered as an anticancer candidate

Post-translational Modification - Reversible protein palmitoylation serves many functions in the cell

Pregnancy - E-cadherin and beta-catenin expression are downregulated in trophoblast

Proliferation and Differentiation - The cell cycle inhibitor p21(Cip1/WAF1) is phosphorylated by Pim-1 kinase

Prostate Cancer - Impaired traffic of connexins is major cause of communication deficiency

Protein Structure - Explanation of structural basis of inward rectification

Protein/Genome Database - IMGT gives access to antibody, receptor, and V-like domains of vertebrates

Proteomics - Calcium sensor in pancreatic beta-cells associates with insulin secretion

Proteomics - SEDL may have regulatory, adaptor functions through protein-protein interactions

Psoriasis - Keratinocyte senescence can occur through multiple types of stimuli

RNA Research - c-Myc directly activates RNA polymerase III transcription

Reproduction - Arc and actin cytoskeleton plays a role in the acrosome formation

Reproductive Behavior - Preliminary evidence suggests control by GnRH-II is energy dependent

Sepsis - IL-6 blockade reduces C5a receptor expression, improving survival

Septic Shock - Tolerance to bacterial lipoprotein enhances survival to many challenges

Stem Cell Research - Basic fibroblast and epidermal growth factors affect neural stem cell activity

Stem Cell Research - Multipotent cell lineages in early mouse development depend on SOX2 function

Stereochemistry - Atomic force microscopy reveals kinks in the p53 response element DNA

Stereochemistry - Integrin beta 3 subunit has an alpha-helical transmembrane domain

Tau Protein - In adult chicken brain, five main tau isoforms are expressed

Topoisomerase IIB - NF-Y and Sp1 binding sites are essential for TOP2B promoter activity

Transcription Regulation - RNA from human dhfr minor transcript alters transcription at the core

Transcriptional Regulation - Myeloid cells require many factors along with retinoic acid to upregulate CD18

Tuberculosis Pathogenesis - Monocyte infection induces unique TNF-alpha enhanceosome

Tuberculosis Pathogenesis - Mycobacteria disrupt TNF-alpha death signals

Varicella Zoster Virus - Mature glycoprotein (gp)E, enabled by gpI, is required for infectivity