Antibacterial Defense
CD1-mediated gamma/delta T cells, TNF alpha can induce dendritic cell maturation
Published in Proteomics Weekly, March 3rd, 2003
"Immature myeloid dendritic cells (DCs) express only low levels of MHC class II but express high levels of CD1 a, b, and c antigen-presenting molecules at the cell surface. As Vdelta1(+) gamma/delta T cells are the main tissue subset of gamma/delta T cells and they are known to recognize CD1c in the absence of specific foreign antigen recognition, we examined the possible interaction of these T cells with immature DCs. We show that CD1-restricted gamma/delta T cells can mediate the maturation of DCs," researchers in the United States report.
"DC maturation required cell-cell contact and could be blocked by antibodies against CD1c. The maturation process was partially...
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Source: Proteomics Weekly (2003-03-03)
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