Published in Proteomics Weekly, March 3rd, 2003
"Regulation of these ion channels via G protein-coupled receptor signaling underlies the control of heart rate and the actions of neurotransmitters in the central nervous system. We have determined the protein structure formed by the intracellular N- and C termini of the G protein-gated inward rectifier K+ channel GIRK1 at 1.8 Angstrom resolution.
"A cytoplasmic pore, conserved among inward rectifier K+ channels, extends the ion pathway to 60 Angstrom, nearly twice the length of a canonical transmembrane K+ channel," wrote M....
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