Transcriptional Regulation
Myeloid cells require many factors along with retinoic acid to upregulate CD18
Published in Proteomics Weekly, March 3rd, 2003
"CD18 (beta2 leukocyte integrin) is transcriptionally regulated in myeloid cells, but the mechanisms that increase its expression in response to retinoic acid (RA) have not been defined. The CD18 promoter was activated by RA treatment in stably transfected U937 myeloid cells. We identified a retinoic acid response element (RARE) that lies nearly 900 nucleotides upstream of the CD18 transcriptional start site that was bound by the RA receptors, retinoic acid receptor (RAR) and retinoic X receptor (RXR)," researchers in the United States report.
"This RARE accounted for one half of the RA responsiveness of CD18. However, unexpectedly, one half of the dynamic response to...
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Source: Proteomics Weekly (2003-03-03)
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