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Proteomics Weekly

Susan Hasty, Publisher

Table of Contents . . . March 31st, 2003

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Proteomics Weekly | Other Publications

Glucose Regulation - Zinc appears to play role in homeostasis

Rhabdomyosarcoma - Gene that drives apoptosis also plays key role in development of skeletal muscle

Cell Biology - USC researchers uncover age discrimination in secretory cells

HIV/AIDS Proteomics - Alternative gp120 V3 loop conformations mimic chemokine beta hairpins

Laboratory Techniques - Scientists track cancer in 3-D, one cell at a time

Research Trends - Reports examine current and future state of proteomics

Virology - Pseudocowpox virus contains a homolog of vascular endothelial growth factor

Adenovirus - A bifunctional ligand protein modifies adenoviral tropism

Allergy Medicine - Chemokine receptors play a key role in inflammatory cell recruitment

Alzheimer Disease - Columbia researchers identify possible new culprit in plaque formation

Apo E Polymorphism - Apolipoprotein E detection in CSF and serum yield the same results

Apoptosis - Granzyme A cleaves the oxidative repair protein Ape1, enhancing cell death

Axonal Degeneration - Blockers of sodium and calcium entry protect axons from nitric oxide

B Cell Activation - A new membrane associated adaptor molecule, LAB, is similar to LAT

Biosequencing - New database of nucleotide and amino acid sequences launched

Blood Brain Barrier - Activated T cells directly affect endothelial cells in inflammation

Brain Damage - High-fat diet may protect newborn brain cells from seizure damage, study says

Breast Cancer - Metastasis and tumor growth suppression achieved with propolis in mouse model

Cell Adhesion/Migration - Recombinant laminin-5 forms reveal two domains involved in normal activity

Cell Biology - Role of heterotrimeric G-protein signaling in plant cell proliferation identified

Cell Cycle - Nuclear phosphatase and tensin homologue is associated with G0-G1

Chronic Hepatitis C - Hepatitis C virus NS2 protein inhibits cellular and hepatitis B gene expression

Cirrhosis -  Rhodiola sachalinensis extract appears to protect from chemical liver injury

Cutaneous T Cell Disease - Endothelial cells induce T-cell chemokine CCL21 in autoimmune patients

Dermatology - A protein cluster links UVB and the induction of growth factor in skin cells

Drug Design - Optimization of therapeutics can be accomplished by directed evolution

Endodontics - Mu-opioid receptors are found in human dental pulp

Environmental Risk - Recent orchidopexy rates don't support endocrine disruptor hypothesis

Gliomal Cell Surface - Stripping proteoglycans of sulfation leads to adhesional and migrational changes

HIV/AIDS Pathogenesis - Syndecan plays key role

HIV/AIDS Proteomics - PDI-mediated reduction of gp120 disulfide bonds needed for virus/cell fusion

HIV/AIDS Therapy - Anti-glycoprotein 41 immunotoxins effective in mice

HIV/AIDS Therapy - Nelfinavir inhibits lymphocyte P-glycoprotein activity

HIV/AIDS Women's Health - C-reactive protein levels predict mortality risk

Helicobacter Pylori - A novel apoptosis-inducing protein complex is related to pathogenesis

Hematology - Strong static magnetic field had no effect on normal lymphocytes

Hematopoiesis - An autocrine-paracrine loop potentiates megakaryocytic maturity through Flt1

Hepatic Metastasis - Interleukin-18 binding protein therapy can neutralize cancer adhesiveness

Hepatitis A Virus - Protein exchanges with hepatitis A virus cover different mechanisms

Hepatology - Cellular density and cell-cell contact mediate plasminogen in hepatocytes

Hyperalgesia - P38 MAP kinase is activated in ganglia and spinal cord postinflammation

Infectious Disease Therapy - The bactericidal agent gentamicin enhances phagocytized bacterial killing

Intestinal Inflammation - Pyrrolidinedithiocarbamate inhibits NF-kappa B and thus IL-8 production

Legionella Pneumophila - The PPIase site of the Mip protein is essential for infection in host

Lung Cancer - Downregulation of the tetraspanin CD9 appears to increase metastatic ability

Lung Cancer - Tumor-derived soluble factors enhance activated T cell apoptosis

Marfan Syndrome - Early miscues cause late problems in model of Marfan syndrome

Memory T Cells - NF-kappa B transcription factors are needed for differentiation

Mosquito-borne Disease - Novel Anopheles gambiae serpin isoforms may mark ookinete invasion

Multiple Sclerosis - Intrathecal IgM synthesis is an indicator of very poor prognosis

Myeloid Growth Suppression - New small unstable apoptotic protein has a different mechanism of action

Narcolepsy - The protein responsible for wakefulness, orexin, is lacking in narcolepsy

Nasopharyngeal Carcinoma - EBV+ cells suffered apoptosis after doxorubicin/BIM2001 combination

Nephrotoxins - The mycotoxin ochratoxin A is found in some Greek wines

Oncology - The binding protein CUGBP2 silences cyclooxygenase-2 expression

Pneumonia - Expression of Duffy antigen on alveolar septa is associated with infection

Prostate Cancer Marker - Cdc25B is an androgen receptor coactivator that is overexpressed

Rheumatoid Arthritis - B7-H1 autoantibodies react with antigen on T cells to induce apoptotic response

Salmonella Infection - Dendritic cells play a key role in immune protection

Sensory Neuropathy - Monoclonal IgM is bound to a trisulfated heparin disaccharide

Spinal Muscular Atrophy - Scientists discover possible new treatment for genetic diseases

Stem Cell Research - Intestinal EP2 receptors mediate prostaglandin effects

Stem Cell Research - Spermatocytes lacking PUF-8 protein revert to mitotic germ cells

Toxoplasmosis - Efficient expression of 3 antigens allows use for diagnostic assay

Transformation Marker - Morules with optically clear nuclei were found in an ovarian cancer

Transplant Medicine - Retinal precursor cells express functional neuronal receptors

Trypanosomiasis - NK-lysin and a shortened synthetic analog NK-2 are potent antiprotozoans

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