Proteomics Weekly

Molecular Biology - The Ets family of transcription factors modulates a variety of functions

Natural Antihistamine - Buckwheat extract inhibits histamine and cytokine release in mast cells

Oral Contraceptives - Elevated antiphospholipid antibodies may increase thromboembolism risk

Otology - Gentamicin produced cochlear hair cell toxicity could be treated with M40403

P53 Ubiquitination - Mdm2 and HPV protein E6 have independent mechanisms for disabling the protein

Pancreatic Cancer - PPAR gamma activation could be therapeutic as it leads to PI3K deactivation

Pancreatic Disease - Pancreatitis-associated protein (PAP) is more common in ductal adenocarcinoma

Pancreatic Metastasis - Epidermal growth factor receptor has higher expression in cancer tissues

Periodontal Disease - Toll-like receptors 2 and 4 are found most in severely inflamed gingival tissue

Plant Immunosuppressant - An Acorus calamus extract is antiproliferative and can alter immune function

Protein Folding - Many accessory proteins are involved in the assembly of MHC-I molecules

Protein Research - Angiogenins participate in angiogenesis and microbe killing activities

Proteomics - BRCA1 E3 ubiquitin ligase activity is enhanced by the BARD1 protein

Proteomics - The angiogenic enzyme CD13/APN is a transcriptional target during morphogenesis

Pseudomonas Aeruginosa - New proteomic techniques reveal workings of bacteria linked to cystic fibrosis

Septicemia - Oxidative stress is the factor that eventually shuts down gene expression

Septicemia - Response to endotoxin was blocked by the synthetic Lipid A analog by E5564

Sexually Transmitted Disease - Prostate-specific antigen useful for studying effects of condom failure

Sideroblastic Anemia - Erythroid mitochondrial ferritin expression may be disease marker

Sjogren Syndrome - Dry eye appears related to infiltrating lymphocytes and acinar cell apoptosis

Skin Blistering Diseases - Desmoglein is a target in autoimmunity and also in staphylococcal infection

Stem Cell Research - HES-1 enhances ex vivo stem cell expansion

Stem Cell Research - Notch signaling and cytokine interactions modulate differentiation

Stem Cell Transplantation - Donor pretreatment with progenipoietin-1 prevents graft-versus-host disease

Sun Protection - Oxidative stress and UVB damage is significantly reduced by topical resveratrol

T Cell-Stimulating Antigens - A change of one amino acid presented by MHCII molecules may trigger disease

Targeted Immunotherapy - The p53 gene encodes a nonmutated epitope recognized by tumor-reactive CTLs

Telomerase - The effects of activation/suppression must be utilized in therapeutic design

Telomerase Activity - A SYBR Green real-time telomeric repeat amplification protocol was developed

Tobacco Use - The stress response to nicotine in periodontal fibroblasts is c-fos induction

Transcription - Chromatin stereochemistry alters transcriptional ability of estrogen receptors

Transplant Medicine - C1 esterase inhibitor and DAF downregulate complement-mediated xenogeneic lysis

Trichinella Spiralis - The tropomyosin gene was cloned, expressed, and is antigenically reactive

Tuberculosis Pathogenesis -  Mycobacterium tuberculosis glycolipoprotein induces macrophage apoptosis

Ubiquitination - Certain conditions creating a stall of RNA polymerase II lead to displacement

Vector Development - Cell-specific targeting makes a new virus-like construct an attractive vector

Vector Development - Smac protein could be a payload for gene therapies

Water Purification - Scientists yield new clues to why bacteria stick to things

Wound Care - Fibroblast-derived thrombospondin 1 and CD36 key to apoptotic cell removal

Xenotransplantation - Induction of B cell tolerance to xenoantigens is a solution