Proteomics Weekly

HIV/AIDS Therapy - Trichosanthin ribosome suppression not linked to antiretroviral effects

Hepatocellular Carcinoma - Overexpression of Gpr49 occurs with beta-catenin mutation

Human Astrocytes - Production of IL-1beta is stimulated by anaphylatoxins plus IL-10

Immunology - Researchers uncover mechanism of class-switching in antibodies

Immunosuppressive Drugs - FR252921 from Pseudomonas fluorescens may target antigen presenting cells

Infectious Disease - Novel immunoassay distinguishes tick-borne from Japanese encephalitis

Listeria Monocytogenes - N-terminal E-cadherin peptides act as decoy receptors for bacteria

Longevity - High levels of anti-inflammatory protein may hold clue to long life in men

Lung Cancer - New high-tech approach identifies two proteins involved in lung cancer

Malaria Pathogenesis - Heparan sulfate mediates binding of infected erythrocytes to endothelial cells

Malaria Pathogenesis - Variable P. falciparum merozoite protein phenotype enhances cell invasion

Malignant Melanoma - Human MIA protein has extended interactions of loops with SH3 domains

Monocytes in Brain - Cells behave differently in endothelial contact than migrating through barrier

Multiple Myeloma - Antibody-producing cells need stress

Multiple Myeloma - Farnesyl transferase inhibitor induces apoptosis in drug resistant cells

Multiple Sclerosis - Apoptosis regulators cFLIP, CD95 are upregulated in relapsing-remitting disease

Multiple Sclerosis - Chronic active lesions have astrocytes expressing B7-1 and B7-2

Multiple Sclerosis - No NF kappa B and AP-1 DNA binding activity was noted to activate T cells

Muscular Dystrophy - Nerve growth factor is expressed in human dystrophic muscles

Nanotechnology - Prions offer nanotech building tool

Nerve Regeneration - Oct6 transcription factor is a good marker for active remyelination

Neuroprotective Protein - Activated protein C blocks apoptosis in ischemic human brain endothelium

Ovarian Cancer - Experimental anticancer agent phenoxodiol induces death of chemoresistant cells

Protein Binding Site - Retinoblastoma suppressor protein binds E2F as well as papilloma oncoprotein

Protein Engineering - Domain swapping in RNase T1 allows acquisition of double-stranded activity

Pseudomonas Aeruginosa - DsbA is essential for multiple virulence factor formation

Pseudomonas Aeruginosa - Host defense requires ceramide-rich membrane rafts to stop septicemia

Research Funding - U.K.-Canadian consortium commits $95 million to genome research project

Schizophrenia - Neuroleptic drugs upregulate interleukin-2 and interferon-gamma in vitro

Scorpion Sting - Plasma cytokines, enzymes, glucose, and venom levels are related

Seborrheic Dermatitis - Skin biopsies show upregulated expression of MICA and cytokines

Sickle Cell Disease - Cationic isothiocyanates show promise for treatment

Skin - Cored tubules are present in human epidermal Langerhans cells

Spirometra Mansoni - An immunoreactive 10 kDa calcareous corpuscle binding protein is identified

Staphylococcal Enterotoxin B - Normal T cells operate on suicidal basis: superantigen induces fratricide

Stem Cell Research - Granulocyte-colony stimulating factor alters dendritic cell CD62L, CCR7 expression

Stem Cell Research - Ikaros proteins involved in myeloid differentiation

Stem Cell Research - Novel cell line grows in erythropoietin or interleukin-3 alone

Toxic Shock Syndrome - Targeting of cytokines involved in the inflammatory cascade may work

Tuberculosis Vaccine - Modified BCG including ESAT-6 provides improved protection

Virology - HCV NS5A protein and human homeodomain protein PTX1 modulate IFN expression

Yeast Infection -  Saccharomyces cerevisiae cell wall can be altered for increased virulence