Proteomics Weekly

Diagnostics - Faster method for creating antibodies in mice discovered

Mutagenesis - Baculovirus expression vector system allows mutant actin protein studies

Breast Cancer - Systemic redundancies may mask the effects of PAI-1 on cancer inactivation

Helicobacter Pylori - Mechanisms of action of Helicobacter pylori virulence factors studied

Herpesvirus - Herpes simplex virus VP16-induced complex investigated

Physiology - Findings in frog oocytes may help study of chromosomes

Allergic Rhinitis - Mast cell product-antagonizing is short-term treatment, long-term solutions needed

Allergic Rhinitis - Rhinitis immunotherapy using specific subcutaneous allergen is better than drugs

Allergies - Latex allergy may create cross-reactive fruit allergies; kiwi is highest risk

Alzheimer Disease - Regulation of glucose by HIF-1 protects neurons from amyloid beta peptide

Anorexia Nervosa - Genes showing differential expression in anorexia mutant mouse identified

Antibacterial Function - Immature dendritic cells have a receptor for human mannan-binding lectin

Antibiotic Research - Resistance may occur in bacteria if innate antibiotic proteins are used

Antibiotics - N- and C-terminal modifications of negamycin affect antibacterial activity

Antifungal Research - Gallerimycin, a moth-derived antifungal peptide, isn't active against yeast

Antimetastatic Action - TSLC1 gene in human lung cancer is probably a cell adhesion molecule

Asthma - Airway epithelium is in constant repair; allergens create cyclic Th2 response

Asthma - Study of glucocorticoid-receptor interactions may lead to new anti-asthma agents

Autoimmune Disease - Autoreactive B lymphocytes may be removable by recombinant fusion proteins

Autoimmune Disease - Some MG seronegative patients may be MuSK antibody positive

Autoimmune Disease - Systemic lupus erythematosus is more prevalent than was previously thought

Autoimmune Disease - Targeted DNA vaccine may reverse disease

B Cell Function - Efficient Vav3 translocation to B cell membrane rafts requires Grb2 and BLNK

Bacteriology - Proteinases secreted by Bacillus intermedius during sporulation studied

Bee Venom - Breast cancer, metastasis, growth reduced with i.v. bee venom therapy in murine model

Biliary Cirrhosis - Symptoms, cirrhosis disease progression are known; cause and cure remain elusive

Biomarkers - New screening for CAR reveals transfection efficiency in cancer cells

Bone Marrow Transplant - Antithymocyte globulin lowers GVHD, worsens T-cell deficiency

Brain Cancer - Welsh study set to accelerate search for new treatment

Cancer Metastasis - Prostate cancer invasion is influenced indirectly by TGF beta1 signals

Cancer Vaccine - Antibody fragments fused to IL-12 and to TNF-alpha exert anti-tumor effect

Cardiology - Exogenous SERCA gene expression depends on CAR levels in cardiac myocytes

Cardiovascular Disease -  GATA4 mutation linked to congenital heart defects

Cell Biology - Scientists create new strain of yeast with 21-amino acid genetic code

Cervical Cancer - Papillomavirus E7 protein blocks pCAF's acetyltransferase, a p53 coactivator

Clear Cell Carcinoma - Three immunohistochemical stains help distinguish clear cell cancer as ovarian or renal

Coagulation - Gln 192 from blood coagulation factor Xa plays key role in function

Cognition - Amyloid-beta peptide impairs short-term but not long-term memory in rats

Cytokine Control - Protein inhibitor of activated STAT3 and androgen receptor compete for STAT3

Cytomegalovirus - Host cell binding prevented for cytomegalovirus coated with AD-2 antibody

DNA Damage Response - Human Spy1 promotes survival of mammalian cells following DNA damage

Dendritic Cell Function - Immature dendritic cells are largely unaffected by apoptotic T cells

Dermatology - Alpha-3-beta-1-integrin regulates hair follicle morphogenesis

Dermatology - EGF receptor may play critical role in suppressing keratinocyte inflammation

Diabetes Complications - Vascular endothelial growth factor is fundamental to diabetic retinopathy

Diagnostic Markers - Trio of AFP, PIVKAII, GGTII increases accuracy of liver cancer diagnosis

Diagnostics - Pediatric Lyme arthritis can be diagnosed using a recombinant IR6 assay

Diarrhea - Intestinal polypeptide antagonists considered as antidiarrhea agents

Drug Design - Drugs must target particular compartment where protein they act upon is located

Endometrial Cell Marker - Cold-inducible RNA-binding protein is downregulated in endometrial carcinoma

Epstein Barr Virus - Inflammatory pseudotumor due to clonal EBV-infected cells can occur in spleen

Escherichia Coli - The StcE gene was probably acquired by E. coli O157:H7 via plasmid

Evolution - An MHC-like region of 19 genes is conserved between humans and fruit flies

Evolutionary Genomics - Pioneering study compares 13 vertebrate genomes

Expression Vectors - Simpler means for making adenoviral cDNA expression libraries have been found

Fish Immunomodulator - Shark cartilage has proteoglycans that stimulate macrophage and B, not T cells

Food Allergy - Recent recommendations for food allergen avoidance in children are reconciled

Food-borne Disease - All Vibrio vulnificus isolates from market oysters are virulent

Gastroenterology - Organelles of Giardia lamblia trophozoite contain cathepsin C activity

Gene Delivery - The new nonviral GE7 vector system takes advantage of overexpressed receptors

Gene Probes - Spotted long oligonucleotide arrays allow for larger scale gene analysis

Gene Transfer - Adenoviral fiber knob modifications overcome refractory transgene expression

Genomics and Genetics - Human autosomal nonsyndromic male infertility gene, CATSPER2, identified

Geriatrics - Proteins that signal amyloid changes in Alzheimer disease are found in PEX

Glioma -  SLIT2 may be glioma tumor suppressor gene

HIV/AIDS - Kappa-opioid, prostanoid EP3 receptors mediate HIV gp120-induced allodynia

HIV/AIDS Neurotoxicity - Neuronal heat shock defenses not activated by HIV gp120

HIV/AIDS Opportunistic Infection - Substance P expression linked to diarrhea severity during cryptosporidiosis

HIV/AIDS Pathogenesis - Downregulation of cell surface CD4 needed for efficient HIV replication

HIV/AIDS Pathogenesis - No direct interaction between Sp1 and HIV Tat proteins

HIV/AIDS Therapy - Proflavine disrupts HIV Rev protein activity

Helicobacter Pylori -  VirB8 homologue essential to secretion system of H. pylori analyzed

Helper T Cells - Inducible costimulator ICOS is involved in T cell activation, IL-4 production

Hematology - Factor VII gene intronic mutation in a lethal factor VII deficiency studied

Hepatology -  PHKA2 gene analysis useful for X-linked liver glycogenosis diagnosis

Herpes Simplex Virus - The HSV ICP8 DNA-binding protein becomes altered upon viral replication setup

Hippocampal - Poly(ADP-ribose) polymerase reduction occurs during stress-related cell death

Histamine Receptor Function - Histamine receptors can bind many molecules, resulting in diverse actions

Hypertension Risk Factor - Activation of central baroreceptor pathway sustained in hypertension

Immune Evasion -  Peptostreptococcus magnus protein L has immunoglobulin binding domains

Immunology -  Hoxa5 gene loss linked to transient setback in murine thyroid development

Immunology - Shark cartilage protein stimulates antitumor immunity in murine models

Infection Susceptibility - Mannose-binding lectin quantity, thus infection resistance, may be genetic

Inflammatory Immunoglobulin - Triggering receptor on myeloid cells can cause sepsis, acute inflammation

Insect Sting Allergy - Insect sting anaphylaxis appears related to mastocytosis, urticaria pigmentosa

Interlukin Expression - IFN-alpha induces binding of IRF-1 and Stat3 to the IL-10 promoter

Intravenous Immunoglobulin - IVIG is immunomodulatory, anti-inflammatory, and provides passive immunization

Kidney Transplant - The use of IVIG in renal transplant may help suppress panel reactive antibodies

Leishmaniasis -  Leishmania major chromosome 3 contains two gene clusters