Amyotrophic Lateral Sclerosis
Characteristic ALS glutamate toxicity may be avoided with NAALADase inhibitor
Published in Proteomics Weekly, September 15th, 2003
"Glutamate toxicity is implicated in the pathogenesis of amyotrophic lateral sclerosis. The neuropeptide N-acetyl-aspartyl glutamate (NAAG) appears to function both as a storage form for glutamate and as a neuromodulator at glutamatergic synapses. N-acetylated-alpha-linked acidic dipeptidase (NAALADase; also termed glutamate carboxypeptidase II) yields N-acetyl aspartate (NAA) and glutamate," scientists in the United States report.
"Prior studies have demonstrated NAALADase upregulation in motor cortex and increased NAAG, NAA...
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Source: Proteomics Weekly (2003-09-15)
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