Central Nervous System
Blocking Rho activation after spinal cord injury prevents cell apoptosis
Published in Proteomics Weekly, September 15th, 2003
"Growth inhibitory proteins in the central nervous system (CNS) block axon growth and regeneration by signaling to Rho, an intracellular GTPase. It is not known how CNS trauma affects the expression and activation of RhoA. Here we detect GTP-bound RhoA in spinal cord homogenates and report that spinal cord injury (SCI) in both rats and mice activates RhoA over 10-fold in the absence of changes in RhoA expression," researchers in Canada report.
"In situ Rho-GTP detection revealed that both neurons and glial cells showed Rho activation at SCI lesion sites," wrote Catherine I....
Want to see the full article?
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Proteomics Weekly
Source: Proteomics Weekly (2003-09-15)
More Articles from Proteomics Weekly
- Huntington Disease
Cell proliferation and neurogenesis increased in Huntington's disease brain - Alzheimer Disease
Melatonin prevents radicals from amyloid peptide and metal ion interactions - Borna Disease Virus
Expression of Borna disease virus phosphoprotein induces abnormalities - Diagnostics
A new sandwich immunoassay for prion detection is faster and more sensitive - Factor XI Deficiency
Two novel mutations involved in severe factor XI deficiency - Multiple Myeloma
Method to predict survival in multiple myeloma developed - More from this issue of Proteomics Weekly
NewsRx is Social
Follow us on your favorite social network by clicking on a button below:
Top Medical Newsletters
Awards
Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005
Facts & Stats
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.
- Google 2010 PageRank: #2 Among Top Health News and Media Publications
- Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
- Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
- Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry
