Published in Proteomics Weekly, September 15th, 2003
"Growth inhibitory proteins in the central nervous system (CNS) block axon growth and regeneration by signaling to Rho, an intracellular GTPase. It is not known how CNS trauma affects the expression and activation of RhoA. Here we detect GTP-bound RhoA in spinal cord homogenates and report that spinal cord injury (SCI) in both rats and mice activates RhoA over 10-fold in the absence of changes in RhoA expression," researchers in Canada report.
"In situ Rho-GTP detection revealed that both neurons and glial cells showed Rho activation at SCI lesion sites," wrote Catherine I....
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