B-Cell Differentiation
The cell cycle plays an integral part in plasma cell biology and dysfunction
Published in Proteomics Weekly, September 15th, 2003
According to a study from the United States, "Cell-cycle control is a major determinant of homeostasis during B-cell development, differentiation, and tumorigenesis. The generation of an antibody response requires activation and expansion of antigen-specific B cells and terminal differentiation of these cells into plasma cells. Plasma cells arrest in the G1 phase of the cell cycle, but the mechanism that underlies timely cell-cycle entry and exit in the humoral immune response is not known.
"The mammalian cell cycle is regulated primarily at the G1-S transition by the...
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Source: Proteomics Weekly (2003-09-15)
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