Proteomics Weekly

Parkinson Disease - Parkinson disease mutant degraded through ubiquitin-proteasome system

Pulmonary Medicine - PPAR-gamma inhibits surfactant protein B gene expression in the lung

Anti-Infectives - New antiviral agents from marine-derived fungus reported

Insulin - Rho subfamily of G proteins regulates insulin secretion from beta cells

Neuroscience - Neuroglobin structure shows distinct mode of controlling O₂ affinity

Salmonella -  Salmonella SipA polymerizes actin using nonglobular protein arms

AIDS Therapy - Novel gp41 crystal structure licensed from Cornell Research Foundation

Airway Branching - Fgf10 for lung morphogenesis is uniform; distal heparan sulfate activate it

Allergy Medicine - Asthma bronchial provocation tests must be created to best mimic reality

Allergy Medicine - Contact dermatitis from cosmetics can come from many sources including perfumes

Allergy Medicine - Determinants of histamine recognition aid design of antihistamines

Allergy Medicine - Fluorescent labelling can be used to screen for allergens with disulfide bonds

Allergy Medicine - Immediate-type allergic reactions occur due to inflamed tissue hyperreactivity

Allergy Medicine - Treatment of side effects in allergen specific immunotherapy isn't standardized

Alzheimer Disease - Quantitative functional brain mapping assesses progress of Alzheimer disease

Alzheimer Disease - TNF-alpha gene polymorphism protects against Alzheimer disease

Alzheimer Disease - Transferrin gene polymorphisms linked to late-onset Alzheimer disease

Anesthesia - Synaptic PDZ protein interactions disrupted by inhalational anesthetics

Anti-inflammatory Effects - Airway epithelium responds to neutrophil elastase with PGE₂ for protection

Anti-inflammatory Effects - Probiotic bacterial homogenates have antiproliferative effects on active PBMC

Antibody Analogue Technology - Protein engineering company reaches technological milestone

Antigen Presentation - Dendritic cells wait at lymph node venules to scan entering T cells for antigen

Antimicrobial Resistance - Mechanism of antibiotic efflux in Gram-negative bacteria reviewed

Antimicrobial Resistance - Multidrug-exporting secondary transporters reviewed

Arthritis Genetics - Two genes involved in arthritis were found in established animal models

Asthma Diagnostics - Sputum eosinophils are the best sputum or blood marker diagnostic for asthma

Asthma Drugs - Montelukast increases phagocytosis, intracellular killing by PML in asthmatics

Autoimmune Disease - Humanized mouse model of inflammatory arthritis may provide insight on tolerance

Autoimmune Disease - LT beta R is essential for proper thymic function and autoimmune control

Autoimmune Disease - T-cell activation can be specifically downregulated by B7x and its receptor

Autoimmune Susceptibility - CARD15 is autoimmune susceptibility gene in Crohn disease, psoriatic arthritis

Bacterial Pathogens -  Shigella IpaC binds to beta-catenin, may be involved in cell-to-cell spread

Bacteriology - Adaptive mutation is common in E. coli

Beryllium Disease - Blood memory T cells are dependent, lung independent of CD28 costimulation

Biosynthesis - New RNase P ribozymes are feasible for use in gene-targeting applications

Biotechnology - Factor XIII improves performance of fibrin sealants

Biotechnology - Impact of biotechnology on future of regulatory toxicology reported

Bipolar Disorder - Dihydropyrimidinase protein gene and bipolar disorder not linked

Brain Tumor - Monocyte chemoattractant protein-1 increases glioma aggressiveness in vivo

Breast Cancer - Competing autocrine pathways regulate breast cancer cell movement

Breast Cancer - Researchers discover how key cancer protein works in inherited forms of disease

Campylobacter - Thermophilic Campylobacter species identified by microarray technique

Campylobacter Jejuni - Transformation in C. jejuni involves several known, several novel genes

Cancer Diagnosis - Scientists test protein as early cancer detection agent

Candidiasis - Assay for diagnosis of disseminated candidiasis developed

Cardiomyopathy - Apoptosis proteins bax and bcl-2, not p53, are increased in cardiomyopathy

Cardiovascular Disease - Apolipoprotein B gene mutations have limited effect on heart disease risk

Cardiovascular Disease - IL-6 superfamily cytokines may play role in heart failure

Cell Biology - Common genetic damages in nondividing cells lead to creation of mutant proteins

Cell Biology - Hypoxia compels macrophages to produce genes linked to pathogenic processes

Cell Biology - Inactivation of beta-catenin causes defective vascular patterns to arise

Cell Biology - Retroviral protein triggers proliferation of immune cells

Central Nervous System - Expression pattern of glypican-1 mRNA after brain injury reported

Cerebral Amyloid Angiopathy - Spontaneous hemorrhage in aging CAA patients may be due to MMP-9

Cholesterol Homeostasis - Hepatic, pancreatic involvement of liver receptor homolog 1 controls cholesterol

Chronic Hepatitis C - Glycyrrhizin uptake may depend on liver organic anion transporting polypeptides

Coagulation - Proteinase-activated receptors can be activated by coagulation proteinases

Colitis - Collagenous colitis with pseudomembrane formation may occur with Ig deficiency

Colitis - High level allograft inflammatory factor-1 reduces IL-1beta, improves colitis

Contractile Diseases - IFN-gamma inhibits myofibroblast formation, may prevent disease progression

Cosmetic Allergy - Sesame oil in cosmetics may cause urticaria in atopic patients or those with skin inflammation

Cytokines - Immunoassay for multiple cytokines is quick and accurate

DNA Repair - Sensors and mediators involved in DNA double-strand breaks defined

DNA Research - DNA condensation by HIV NCp7 has protective role

Dementia - FBD amyloid is made of the abnormal C-terminal fragment of BRI and furin

Demyelinating Disease - Chronic inflammatory demyelinating polyneuropathy may be treatable with IVIg

Demyelinating Polyneuropathy - CIDP with a low response to therapy may have other underlying disease or cancer

Dermatology - Cutaneous manifestations can initiate Waldenstrom macroglobulinemia

Developmental Biology - Effects of ETA signaling on neural crest development clarified

Diabetes Pathogenesis - Secretion coupling by ATP:ADP involved in insulin stimulus

Diagnostics - Native separation and femtomolar detection of zinc proteins developed

Diagnostics - Two mass spectrometry methods comparably measure total homocysteine in serum

Drug Delivery - Drugs may have altered ability to cross blood-brain barrier if there is pain

Drug Development - Novasite wins NIH grants for drugs targeting serotonin receptors

Drug Development - Rational design useful for development of HIV-stimulating agents

Drug Resistance - Novel enzymatic test quickly determines HIV PI resistance

Enzymology - Iodothyronine selenodeiodinases have active site similar to iduronidase

Epidermolysis Bullosa - Lethal epidermolysis bullosa is due to low or lack of integrin beta 4

Erythema Multiforme - Antidesmoplakin autoantibodies enter keratinocytes via plasmalemmal vesicles

Estrogen Deficiency - Estrogen deficiency causes bone loss by T-cell proliferation, lifespan increase

Finance - BeadArray developer reports 176% revenue increase in third quarter

Finance - Proteomics company announces $6 million financing

Foot and Mouth Disease - FMDV RNA polymerase has a hypermutation region, may help in immune evasion

Fungal Infections -  Histoplasma capsulatum is an effective intracellular pathogen

Fungal Infections - How the immune system reacts to fungal pathogens is beginning to be understood

GI Function - Intestinal heat shock protein 110 induces CD1d in epithelial cells

Gene Transfer - BAD overexpression improves the way anchorage-loss encourages apoptosis

Gene Transfer - Human serum albumin-polyethylenimine nanoparticles power transfection ability

Genetics and Genomics - MODY is model of genotype/phenotype interactions in type 2 diabetes

Genetics and Genomics - West African Pygmies have some unique HLA class I alleles and haplotypes

Geriatric Cardiology - Adenosine receptor gene expression heightened in senescent rat heart

Geriatrics - An early event in Alzheimer disease may be activation of caspase-3

Geriatrics - Noggin expression thwarts bone health in aging animal models

Geriatrics - Nuclear estrogen receptor-alpha is not in Alzheimer affected neurons

Guillain-Barre Syndrome - Cases of Guillain-Barre syndrome can have pleocytosis or CSF granulocytes

HIV/AIDS Dementia - HIV and IL-1beta regulate astrocyte FasL expression through the NF-kappa B pathway

HIV/AIDS Pathogenesis - HIV Nef does not affect the efficiency of viral cell fusion

HIV/AIDS Pathogenesis - HIV Vpu prevents apoptosis of infected CD4 cells

HIV/AIDS Pathogenesis - Prognostic CCR5 mutations affect co-receptor expression