Antisense Technology

Bcl-x(L) antisense oligonucleotides sensitize colon cancer cells to radiation

Published in Proteomics Weekly, November 24th, 2003

Bcl-x(L) antisense oligonucleotides sensitize colon cancer cells to radiation.

"Advanced colon cancer is a malignancy with poor response to various treatment modalities including ionizing radiation (IR) and chemotherapy. Both IR and chemotherapeutic agents have been shown to act by inducing apoptosis, a type of cell death antagonized by the Bcl-x(L) gene product. Since approximately 60% of human colon cancers express Bcl-x(L), it was the aim of this study to explore the potential of Bcl-x(L) antisense oligonucleotides as a novel radiosensitization strategy," scientists in Austria report.

"Caco-2 colon cancer cells were treated with Bcl-x(L) antisense...

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Source: Proteomics Weekly (2003-11-24)

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