Proteomics Weekly

T-Cell Proliferation - T-cell apoptosis can be induced by cell cycle regulator p21 or peptide DQ 65-79

Thrombosis - FDA approves lab tests for genetic clotting risk

Toxicology - Bisphenol A metabolite levels in urine are gender-dependent

Trypanosoma - Structure of thioredoxin from Trypanosoma brucei brucei determined

Tuberculosis -  M. tuberculosis ethA and inhA gene mutations linked to ethionamide resistance

Tuberculosis Genomics & Genetics -  M. tb strains have differential PE, PE_PGRS gene expression

Tuberculosis Immunology - Novel CD8 cell epitope shared by M. tuberculosis ESAT-6 proteins

Tumor Necrosis Factor - There are several multimeric forms of RANKL involved in osteoclastogenesis

Vaccine Safety -  Vibrio cholerae toxins activate proinflammatory immune response

Bacteriology - Needle length of bacterial injectisomes determined by molecular ruler

Amyloidosis - C-terminal of beta 2-microglobulin plays role in amyloid fibril formation

Vascular Endothelium - Activated lymphocyte, neutrophil migration may be regulated by L-selectin

Vectors and Zoonoses - Single gene encoding VDAC protein identified in Anopheles gambiae

Viral Proteomics - Antivirals are tools for analyzing hepatitis B virus genomic replication

Viral Proteomics - Hemagglutinin uses "leash in the groove" mechanism for membrane fusion

Anesthetics - Protein kinase C plays role in action of volatile anesthetics

Angiology - Elastin induces myofibrillogenesis via VGVAPG domain

Animal Models - Heart and eye disorders in murine MPS IV model identified

Anthrax - Anthrax mounts nuclear attack on glucocorticoid signaling

Anthrax - Calcium may play role in folding pathway of anthrax protective antigen

Anti-Inflammatory - Binding site for anti-inflammatory tripeptide feG identified

Antibiotic Research - Study of E. coli given cecropin B reveals antibiotic's mode of action

Antigen Presentation - Full T-cell expansion, function require days of exposure to antigen complex

Antigen Presentation - Uptake of polioviral RNA creates antigen by neosynthesis, specific CTL result

Gastric Cancer - Cyclooxygenase-2 contributes to gastric carcinogenesis

Antigen-Presenting Cells - APC-expressed indoleamine 2,3-dioxygenase degrades tryptophan; lowers atopy

Antimicrobial Peptides - Cathelicidins vary in resistance to proteolysis; some have sustained activity

Antimicrobials - New classes of antibacterial oxazolidinones reported

Antitumor Therapy - RNA aptamers can bind and inhibit CTLA-4, increasing antitumor activity

Apoptosis - Peptide increases arachidonic acid release and apoptosis of muscle cells

Apoptosis - Targeting lipid raft protein distribution may control apoptosis

Arthritis Pathogenesis - Arthritis-regulating quantitative trait locus on rat chromosome 6

Asthma - Corticosteroids do not appear to prevent early bronchial remodeling

Asthma - Exposure of babies to mite, cat can lead to asthma; repeat rhinitis lowers risk

Autoimmune Disease - Autoreactive B cells infected with EBV may be key to chronic autoimmune disease

Genetic Disorder - Mutations in polyglutamine binding protein 1 gene cause mental retardation

Autoimmune Disease - CNS autoimmune disorders may benefit from the statin anticholesterol drugs

Autoimmune Disease - EEA1 has many B cell epitopes; neurological disease may occur if at C terminal

Bacteriology - Amino acids and peptides may help protein removal and innate lung defense

Bacteriology - Chemical signaling among bacteria and its inhibition reviewed

Bacteriology - DNA-membrane interactions can localize bacterial cell center

Botulinum Toxin - Electrophoresis method to evaluate botulinum toxin activity developed

Brain Tumor - Matrix metalloproteinases are tumor-specific markers in glioma patients

Breast Cancer - Research paves way for individualized treatment

Breast Cancer - Tamoxifen has no effect on p27 protein expression in endometrium

CNS Disease - Extracellular phospholipase A2 inhibitors can inhibit inflammation in CNS

Glioma - P-glycoprotein mediates multidrug resistance in malignant glioma cell lines

Cancer Therapy - Data presented on treatment to combat effects of chemotherapy

Cardiology - Hypoxia-inducible factor 1 regulates several factors to control angiogenesis

Cardiovascular Disease -  MTHFR mutation significantly raises hyperhomocysteinemia risk in children

Cardiovascular Disease - Changes in skeletal muscle gene expression during CHF elucidated

Cardiovascular Disease - Genetic and environmental risk factors for extremely high cholesterol levels identified

Cardiovascular Disease - Losartan may reduce risk of platelet-induced pulmonary thromboembolism

Cardiovascular Disease - Protein kinase C changes RKIP target from Raf-1 to GRK-2

Cardiovascular Disease - Selenium may protect against heart attacks in men

Cardiovascular Disease Therapy - Prevention of SR alterations may underlie beneficial effects of heart failure treatments

Cardiovascular Disease Therapy - Suppression of cardiomyocyte apoptosis has little effect on efficacy of MI treatments

SARS - Researchers assess putative protein targets derived from the SARS genome

Cartilage Repair - Fibrin-chondrocyte constructs can be used to perform cartilage repair

Celiac Disease - Knowledge of gluten-processing path should help celiac disease therapy emerge

Cell Biology - A big surprise: Young nerve cells can rewind their developmental clocks

Cell Biology - Endothelial cell-specific response characterizes VEGF receptor stimulation

Cell Counting - An SAP staining procedure is equal or better than IF for HbF cell counting

Central Nervous System - Ap-1 targets in the brain reviewed

Charcot-Marie-Tooth Syndrome - Late onset Charcot-Marie-Tooth 2 syndrome caused by mutations in MPZ gene

Chemokine Receptors - The E3 ubiquitin ligase AIP4, Hirs, and Vps4 coordinate CXCR4 ubiquitination

Class Switch Recombination - Class switch recombination has unique DNA recognition structures for enzymes

Cocaine Testing - An anti-BZE coated sensor can detect residual cocaine vapor plumes in the air

Addiction Medicine - Amphetamines and cocaine regulate dopamine transporter function

Creutzfeldt-Jakob Disease - In cerebellum of Creutzfeldt-Jakob patients, nestin increases with severity

Crystallography - Complement protein C1q has a trimeric, spherical shape that may aid binding

Cystic Fibrosis - The A561E cystic fibrosis mutation is a class II, protein trafficking defect

Dendritic Cell Function - Cyclosporine may induce tolerogenesis by reducing dendritic cell IL-2, IL-12

Depression - Depression may be linked to proinflammatory cytokine-serotonin interaction

Developmental Biology - New roles for protein modifications in cell migration

Diabetes Pathogenesis - Muscle-specific Pparg deletion causes insulin resistance

Drug Resistance - FLICE inhibitory protein supports chemoresistance in cervical cancer

Embryonic Research - Slit3 protein involved in heart, kidney and diaphragm development

Endocrinology - Ectopic ghrelin expression enhances growth

Allergic Rhinitis - Pranlukast reduces levels of cytokines, eosinophils in rhinitis nasal mucosa

Environmental Exposure - Atrazine contamination in water can be detected with a sensitive immunoassay

Enzymology - Calcineurin anchoring and cell signaling reviewed

Enzymology - Extracellular matrix signals collaborate to govern angiogenesis

Enzymology - Lipoxygenase makes transgenic tobacco less vulnerable to parasitic infection

Escherichia Coli - Latex agglutination, EIA are comparable tests for shiga toxin-E. coli

Food-borne Illness - Major cause of painful gastroenteritis under study at the Medical College of Georgia

Fungal Infection - Mycosis fungoides has changes in T-cell chemokine receptors that depend on stage

Gastric Ulcer - Receptors play role in vascular effects of adrenomedullin in gastric ulcers

Gastroenterology - Glucagon-like peptide-2 is not the only enterotrophin

Gene Expression - Companies renew commitment to gene expression tool

Allergy Medicine - Allergy to goat, sheep milk, but not cow, is due to greater casein homology

Genetic Disorder - Familial Mediterranean fever with amyloidosis linked to mutation of MEFV gene

Genetic Disorder - Kinesin KIF21A mutations linked to congenital fibrosis

Genetic Disorder - PANK2 mutations confirm HARP and Hallervorden-Spatz syndromes are allelic

Genetic Engineering - Reengineered dendritic cells readies cytotoxic T cells for select epitopes

Genital Herpes - Antibodies to HSV-2 glycoprotein G are not always there during primary infection

Genomics and Genetics - Mutations affecting lipoprotein phenotype in South European FH patients identified

Genomics and Genetics - Oxidative DNA damage underlies mitochondrial effects of cancer, HIV drugs

Gynecology - Adenovirus-mediated suicide gene therapy destroys ovarian cancer cells

HIV/AIDS Proteomics - HIV Tat interacts with Notch protein EGF-like repeats and the EGF precursor

HIV/AIDS Proteomics - HIV Vif induces G₂ /M arrest in feline and bovine cells