Hematology
Thrombin interaction with platelet membrane glycoprotein Ib alpha discussed
Published in Proteomics Weekly, January 19th, 2004
"The interaction of thrombin with platelet glycoprotein Ib-alpha (GPIb-alpha) is required for optimal platelet activation. The crystal structures of platelet GPIb-alpha bound to thrombin reported by Dumas et al. and Celikel et al. both reveal the simultaneous interaction of GPIb-alpha with thrombin exosites I and II but differ markedly regarding how the two proteins interact," investigators in France report.
"The possible consequences on thrombus formation of thrombin interacting with...
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Source: Proteomics Weekly (2004-01-19)
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