Ophthalmology

Acid bindings to interphotoreceptor retinoid-binding protein compared

Published in Proteomics Weekly, January 26th, 2004

Researchers have published a comparison between oleic acid and docosahexaenoic acid binding to interphotoreceptor retinoid-binding protein in a recent issue of Vision Research.

"Interphotoreceptor retinoid-binding protein (IRBP), which binds retinoids and fatty acids, is the major soluble protein in the interphotoreceptor matrix (IPM) but its role remains ambiguous. Using competitive fluorescence and tryptophan-quenching assays we found oleic acid and other cis-monounsaturated fatty acids bind much more strongly than does docosahexaenoic acid to bovine IRBP," investigators in Scotland report.

"IPM's fatty acid composition was determined: it...

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Source: Proteomics Weekly (2004-01-26)

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