Pain Medicine

Protein kinases C and A play different roles in pain in mice

Published in Proteomics Weekly, January 26th, 2004

Spinal protein kinase C and protein kinase A play different roles in neuropathic and inflammatory pain in mice.

"In the present study, we demonstrated the differential role of spinal protein kinases in neuropathic and inflammatory pain. Mice with sciatic nerve ligation exhibited a spinal protein kinase C (PKC)-dependent neuropathic pain-like state. In contrast, an intraplanter injection of inflammatory agent caused a protein kinase A (PKA)-related thermal hyperalgesia," researchers in Japan report.

"These findings suggest that the substantial activation of spinal PKC and PKA may differentially contribute to the development of respective chronic...

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Source: Proteomics Weekly (2004-01-26)

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