Published in Proteomics Weekly, February 2nd, 2004
In the Journal of Clinical Investigation, Domenico Accili and colleagues from Columbia University in New York City addressed this question by generating mice that lacked the gene encoding the insulin receptor (Insr) in a varying percentage of their body's cells.
The authors characterized mouse strains with 80% (.80) and 98% (.98) reduction in Insr levels and found that both strains exhibited severely stunted growth....
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