Cell Biology

Independent roles for insulin found in metabolism and cellular growth

Published in Proteomics Weekly, February 2nd, 2004

Insulin regulates how we store and use our food as fuel and also controls cellular proliferation. A question that remains is whether insulin promotes cell growth independent of metabolism, or are the two processes interdependent'

In the Journal of Clinical Investigation, Domenico Accili and colleagues from Columbia University in New York City addressed this question by generating mice that lacked the gene encoding the insulin receptor (Insr) in a varying percentage of their body's cells.

The authors characterized mouse strains with 80% (.80) and 98% (.98) reduction in Insr levels and found that both strains exhibited severely stunted growth....

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Source: Proteomics Weekly (2004-02-02)

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