Proteomics Weekly

Drug Resistance -  N. gonorrhoeae protein mutant allows entry of antimicrobials

Genomics & Genetics - Gene for vitamin K epoxide reductase identified

Alzheimer Disease - ACE gene polymorphism linked to damage in Alzheimer disease

Myelodysplastic Syndrome - Protein 4.1 deficiency linked to acquired elliptocytosis

Oligodontia - Missense mutation in PAX9 causes non-syndromic oligodontia

Schizophrenia - Impaired AKT1-GSK3 beta signaling plays role in schizophrenia

Acute Coronary Syndrome - Analysis from TACTICS-TIMI 18 trial published

Addiction Medicine - GABA_B receptor agonists exert bidirectional effects on dopamine

Adipose Tissue - Preadipose cell changes into smooth muscle-like cells investigated

Allergy Medicine - Increased thrombin activity occurs after allergen challenge

Alzheimer Disease - A-beta antibody levels not changed in patients with Alzheimer disease

Alzheimer Disease - Physiological role of beta-amyloid peptide explains Alzheimer disease

Angiology - Matrix metalloproteinase-9 is needed for revascularization after ischemic injury

Angiology - Polymorphism in gene promoter linked to increased bilirubin and HDL levels

Angiotensin - Angiotensin II attenuates caspase-3 activation in cortical neurons

Antibiotics - Major determinants of activity of antibiotic peptide described

Atherosclerosis - Endothelial catalase overexpression attenuates oxidant-mediated injury

Bacillus - Method to identify protease genes from B. thuringiensis developed

Bacteriology - Acyl-homoserine lactone binding in Vibrio fischeri is reversible

Bacteriology - YefM antitoxin family carries novel antibacterial target

Biotechnology - Peptide array used to identify Ang II inhibitory peptide

Bovine Spongiform Encephalopathy - Projections of beef production drop following mad cow disease scare

Breast Cancer - Estrogen interacts with estrogen receptor and SP proteins to control VEGF

Cancer Metastasis - Platelet-activating factor boosts the activation of proangiogenic cytokines

Cancer Therapy - Decoy receptor 3 can be suppressed to staunch tumor angiogenesis

Cancer Therapy - Higher doses would make taxane-mediated antiangiogenesis more effective

Cancer Therapy - Polo-like kinase 1 is a viable target for the treatment of prostate cancer

Cancer Therapy - Semaphorin-3F curtails tumor angiogenesis

Cancer Therapy - Spacer-containing doxorubicin prodrugs limit tumors without systemic toxicity

Candidiasis - Protease-inhibitor cocktail protects, increases antimicrobial action of new peptide

Cardiology - AT₂ -receptor antagonists block Ang II effects on atrial noradrenaline release

Cardiovascular Disease - AT₁ receptors linked to insulin resistance-induced vascular dysfunction

Cardiovascular Disease - Angiotensin II causes oxidative stress in hypertension patients

Cardiovascular Disease - GATA-4 transcription factor regulates cardiac myocyte apoptosis

Cardiovascular Disease - GP Ialpha genotype affects CHD risk

Cell Biology - Scientists publish details of how nutrients, other molecules get into cells

Cloning - Life science company introduces RapidTransit Transformation Kit

Collaborations - Biotech firm grants non-exclusive license on its DPD-process to Roche

Complementary & Alternative Medicine - Green tea finds a tumor cell

Contraception - Progestins mitigate thrombotic risk of contraceptive estrogens

Cytokines - Interleukin-4 inhibits preadipocyte proliferation

Dengue Virus - Dengue virus receptor molecules isolated by affinity chromatography

Diabetes Pathogenesis - Apoptosis of insulin-secreting cells investigated

Diagnostics - Generex developing kit for early detection of type 1 diabetes in young children

Diagnostics - Recovery of radioactively labeled proteins from gels investigated

Distribution Agreement - LSBC enters biomanufacturing and commercial distribution agreement

Drug Development - Pertussis toxin B-oligomer is pleiotropic HIV Tat inhibitor

Drug Development - Resonance energy transfer monitors the delivery of angiogenic proteins

Drug Resistance -  Staphylococcus lentus gene encodes resistance to chloramphenicol

Drug Resistance - Ribosomes contribute to bacterial resistance against antibiotic

Endocrinology - Atypical protein kinase C is target of TC10 signaling pathways

Endocrinology - Chromogranin A offers vessels protection against TNF-alpha-induced leakage

Enzymology - C-terminal Src kinase facilitates angiogenic sprouting and vascular remodeling

Enzymology - Protein kinase C negatively modulates integrin expression

Fraser Syndrome - Link found between the protein GRIP1 and Fraser syndrome protein Fras1

HIV/AIDS Dementia - CXCR4 mediates gp120 neurotoxicity in cerebellar granule cells

HIV/AIDS Drug Resistance - Crystal structures of NNRT-resistant HIV RT characterized

HIV/AIDS Epidemiology - Ottawa HIV "superinfection" case did not carry superinfection

HIV/AIDS Pathogenesis - HIV matrix serine phosphorylation in early postentry replication clarified

HIV/AIDS Perinatal Medicine - HIV coreceptor expression determined in exposed but uninfected infants

HIV/AIDS Proteomics - Assembly properties of HIV CA protein determined

HIV/AIDS Proteomics - Effects of P-TEFb on HIV transcription elucidated

HIV/AIDS Proteomics - HIV Vif protein post-translationally modified by ubiquitin

HIV/AIDS Proteomics - Protease activity regulates Env-mediated membrane fusion

HIV/AIDS Proteomics - Tat from HIV subtype C has impaired chemotactic ability

HIV/AIDS RNA Research - Perinuclear HIV RNA release mediated by hRIP

HIV/AIDS Vaccine - HIV-1 Nef delivery to dendritic cells may stimulate immune response

Head & Neck Cancer - Angiogenic protein marks oral squamous cell carcinoma prognosis